KIDNEY FUNCTION IN NON-INSULIN-DEPENDENT DIABETES MELLITUS

肾小球的功能特征正在被 在吉拉河印第安社区的皮马印第安人中进行了调查， 确定潜在的发病机制参与启动 非胰岛素依赖型糖尿病肾病的进展 糖尿病（NIDDM）。 皮马印第安人的NIDDM和糖尿病发病率很高， 肾病 正在研究六组受试者： 正常葡萄糖耐量，葡萄糖耐量受损个体 (IGT)，新诊断糖尿病患者（NIDDM持续时间<3年），以及 糖尿病受试者（持续时间超过5年的NIDDM），有（a.） 轻度异常白蛋白排泄（B.）严重白蛋白异常 排泄（c.）正常白蛋白排泄。 肾脏和 肾小球毛细血管壁功能，包括肾小球滤过率 (GFR)、肾血浆流量（RFP）、葡聚糖筛分系数，以及 白蛋白尿正在进行和相关。 标志物和/或预测物 以及启动和进展的机制， 糖尿病肾病正在寻找中。

The functional characteristics of the renal glomerulus are being investigated in Pima Indians of the Gila River Indian Community to identify the underlying pathogenetic mechanisms involved in the initiation and progression of renal disease in non-insulin-dependent diabetes mellitus (NIDDM). The Pima Indian population has a high incidence of NIDDM and diabetic nephropathy. Six groups of subjects are being studied: subjects with normal glucose tolerance, individuals with impaired glucose tolerance (IGT), those with newly diagnosed diabetes (<3 years duration NIDDM), and diabetic subjects (more than 5 years duration NIDDM) with evidence of (a.) mildly abnormal albumin excretion (b.) severe abnormalities of albumin excretion (c.) normal albumin excretion. Measurements of renal and glomerular capillary wall function including glomerular filtration rate (GFR), renal plasma flow (RFP), dextran sieving coefficients, and albuminuria are being performed and correlated. Markers and/or predictors of progression as well as the mechanisms of initiation and progression of diabetic renal disease are being sought.