Defining the apoptotic and therapeutic activities of histone deacetylase inhibitors

HDAC抑制剂(HDACi)是一种新的化疗药物，它通过一种称为细胞凋亡的细胞自杀过程来杀死肿瘤细胞。我们已经使用了人类血癌的小鼠模型来表明，这些抑制剂可以安全地用于严重限制血癌的生长和扩散。HDACi有能力抑制多种不同的靶蛋白(HDAC)，我们的目标是识别癌细胞保持存活所需的关键HDAC。这些信息将导致使用HDACi进行更有针对性或更合理的化疗方法。

HDAC inhibitors (HDACi) are new chemotherapeutic drugs that kill tumors cells through a cell suicide process called apoptosis. We have used a mouse model of human blood cancers to show that these inhibitors can be used safely to severely limit the growth and spread of blood cancers. HDACi have the ability to inhibit multiple different target proteins (HDACs) and we aim to identify the key HDACs that cancer cells require to remain viable. Such information will lead to a more targeted or rational approach to chemotherapy using HDACi.