ANIMAL MODELS FOR VIRAL HEPATITIS RESEARCH

该计划的目标是维持大约100只动物 (85种非人类灵长类动物，包括多达25名婴儿和青少年 黑猩猩和多达60只绒猴或猴子；以及多达25只其他小型动物 动物，主要是土拨鼠，但偶尔也有兔子和豚鼠) 用于各种病毒性肝炎研究。所有动物都将被关在笼子里 以及将由政府提供的内庭单位。研究 在这些动物身上进行的实验将包括，但不是 仅限于：给动物接种各种肝炎制剂， 监测动物的疾病迹象，进行治疗性治疗 方案，以及按所提供的方案描述的标本采集 由项目官员提供。由项目官员设计的研究可 包括：建立传染性病毒池和/或滴定池， 测试疫苗和其他免疫预防药物，并确定 感染途径以及抗病毒药物和免疫调节剂的作用。 SEMA的技术和专业人员将执行 由项目官员提供的实验方案。工作人员 将喂食、浇水和照料所有动物，并为 由项目官员提供病毒材料的灵长类动物，收集 血液和组织样本，进行身体检查，并提供 治疗、进行尸检和其他实验程序，如 剖腹探查术、开腹肝活检和淋巴结活检。 在大多数研究中，预计SEMA将进行鼻腔手术 咽拭子，气管内灌洗，灌胃，收集脊髓液， 血清和尿液，进行血浆置换，白细胞渗透，骨髓 肝活检，有时还会做腹部手术 收集多达50克的肝脏。

The objective of this program is to maintain approximately 100 animals (85 non-human primates, including up to 25 infant and juvenile chimpanzees and up to 60 marmosets or monkeys; and up to 25 other small animals, primarily woodchucks, but on occasion rabbits and guinea pigs) for various viral hepatitis studies. All animals will be held in cages and chamber units which will be provided by the Government. Studies which will be performed on these animals will include, but not be limited to: inoculation of the animals with various hepatitis agents, monitoring the animals for signs of disease, treating with therapeutic regimens, and collecting specimens as described by protocols furnished by the Project Officer. The studies designed by the project Officer may include: establishing infectious virus pools and/or titrating pools, testing vaccines and other immunoprophylactic agents, and determining routes of infection and the effect of antivirals and immunomodulators. The technical and professional staff of SEMA will perform the experimental protocols as provided by the Project Officer. The staff will feed, water and care for all animals as well as inoculate the primates with viral material provided by the Project Officer, collect blood and tissue samples, perform physical examinations and provide treatment, perform necropsies and other experimental procedures such as exploratory laparotomies, open liver biopsies, and lymph node biopsies. For most of the studies, it is anticipated that SEMA will perform nasal and throat swabs, intratracheal lavage, gavages, collect spinal fluids, sera, and urine, perform plasmapheresis, leukophoresis, bone marrow aspirations, needle liver biopsies, and on occasion abdominal surgery to collect up to 50 grams of liver.