KIDNEY FUNCTION IN NON-INSULIN-DEPENDENT DIABETES MELLITUS

肾小球的功能特征是 在皮马调查吉拉河印第安人社区 确定涉及到的潜在致病机制 非胰岛素依赖型肾脏疾病的发生和发展 糖尿病(NIDDM)。 皮马印第安人NIDDM和糖尿病的发病率很高 肾病。目前正在研究六组受试者：受试者 糖耐量正常，糖耐量受损的人 (IGT)，新诊断的糖尿病患者(&lt；3年病程NIDDM)， 和糖尿病受试者(病程大于或等于5年的NIDDM) 有证据证明(a.)轻度异常白蛋白排泄(b.)严重 白蛋白排泄异常(c.)白蛋白排泄正常。 肾和肾小球毛细血管壁功能的测量包括 肾小球滤过率(GFR)、肾血浆流量(RPF)、葡聚糖过筛 系数，和蛋白尿，正在进行和相关。 进展的标志物和/或预测因子以及 糖尿病肾病的发生和发展是目前研究的热点。

The functional characteristics of the renal glomerulus are being investigated in Pima Indians of the Gila River Indian Community to identify the underlying pathogenetic mechanisms involved in the initiation and progression of renal disease in non-insulin-dependent diabetes mellitus (NIDDM). The Pima Indian population has a high incidence of NIDDM and diabetic nephropathy. Six groups of subjects are being studied: subjects with normal glucose tolerance, individuals with impaired glucose tolerance (IGT), those with newly diagnosed diabetes (<3 years duration NIDDM), and diabetic subjects (greater than or equal to 5 years duration NIDDM) with evidence of (a.) mild abnormal albumin excretion (b.) severe abnormalities of albumin excretion (c.) normal albumin excretion. Measurements of renal and glomerular capillary wall function including glomerular filtration rate (GFR), renal plasma flow (RPF), dextran sieving coefficients, and albuminuria are being performed and correlated. Markers and/or predictors of progression as well as the mechanisms of initiation and progression of diabetic renal disease are being sought.