ORAL HEALTH AND SALIVARY FUNCTION IN HIV-1 INFECTED PATIENTS

这个项目的重点是与HIV-1感染相关的口腔变化。我们 已经检查了唾液，口腔防御系统的关键部分， 感染后的变化。HIV-1阳性患者的唾液分泌物 唾液腺增大患者(HIV-SGD)，类似于 对干燥综合征患者的临床资料进行了分析。唾液中的IgA水平升高， HIV-1阳性患者中存在乳铁蛋白和IgA类风湿因子 唾液腺增大的患者比HIV-1阳性患者 没有放大。然而，来自初发患者的唾液 干燥综合征患者唾液中的IgA、乳铁蛋白、 和Ig A RF。44%的HIV-SGD患者也有唾液 识别唾液上皮细胞胞浆的自身抗体 但自身抗体不是抗SS-A、抗SS-B或抗DNA。 相比之下，73%的原发性干燥综合征患者有抗SS-A抗体 或反SS-B。约200名HIV-1血清阳性者的牙周状况 对患者进行评估(见Z01-DE-000498-02)。HIV相关性牙周炎 没有被发现，与艾滋病毒相关的牙周炎更常见。初步 数据表明，没有罕见的病原体与艾滋病毒-牙周炎有关。 在50%的唾液样本中发现了HIV-1前病毒序列 艾滋病毒-1血清阳性患者(见Z01 DE-00423-06)。尽管看起来 HIV-1病毒不是通过唾液传播的，这一发现表明 唾液可能会传染。儿童牙周炎的口腔表现 目前正在对感染HIV-1病毒的患者进行研究。

This project focuses on oral changes associated with HIV-1 infection. We have examined saliva, a critical part of the oral defense system, for changes following infection. Salivary secretions from HIV-1 positive patients with salivary gland enlargement (HIV-SGD) which mimics that seen in Sjogren's syndrome were analyzed. Higher elevations of salivary IgA, lactoferrin, and IgA rheumatoid factor (RF) were present in HIV-1 positive patients with salivary gland enlargement than in HIV-1 positive patients with no enlargement. However, the saliva from patients with primary Sjogren's syndrome had much higher levels of salivary IgA, lactoferrin, and IgA RF. Forty-four percent of patients with HIV-SGD also had salivary autoantibodies that recognized the cytoplasm of a salivary epithelial cell line, but the autoantibodies were not anti-SS-A, anti-SS-B, or anti-DNA. In contrast, 73% of patients with primary Sjogren's syndrome had anti-SS-A or anti-SS-B. Periodontal status in approximately 200 HIV-1 seropositive patients was assessed (see Z01-DE-000498-02). HIV-associated periodontitis was not found, and HIV-associated gingivitis was more common. Preliminary data suggest no uncommon pathogens are associated with HIV-gingivitis. HIV-1 proviral sequences were found in 50% of whole saliva samples from HIV-1 seropositive patients (see Z01 DE-00423-06). Though it appears that HIV-1 is not spread through a salivary route, the finding suggests an infectious potential for saliva. The oral manifestations of pediatric patients with HIV-1 infection are currently being studied.