CHARACTERIZATION OF IMMUNE RESPONSES TO S-ANTIGEN

实验性自身免疫性葡萄膜炎（EAU）是一种由自身免疫性葡萄膜炎诱导的疾病模型。 遗传易感动物通过注射各种可溶性视网膜 抗原佐剂。这些抗原中最具特征的是S-Ag。的 它诱导的葡萄膜炎严重依赖于激活的T细胞的存在， 细胞已经确定，T细胞由于以下原因而被激活： 它们与引发的抗原呈递细胞的相互作用， 其中诱食蛋白被内化并被部分消化。 来自原始蛋白质的片段然后在细胞上重新表达 它们可以与T细胞相互作用的表面。正在开展工作， 确定和描述那些负责 在动物和人类中的临床反应。

Experimental autoimmune uveitis (EAU) is a disease model induced in genetically susceptible animals by injection of various soluble retinal antigens in adjuvant. The best characterized of these antigens is S-Ag. The uveitis it induces is critically dependent on the presence of activated T cells. It has been established that T cells become activated as a result of their interaction with primed antigen-presenting cells, a process through which the enciting protein is internalized and partially digested. Fragments from the original protein are then reexpressed on the cell surface where they can interact with T cells. Work is being carried out to identify and characterize those fragments which are responsible for the clinical response in animals as well as in humans.