NEUROBIOLOGICAL BRAIN ABNORMALITIES IN SCHIZOPHRENIA

这项神经科学研究中心提案的主旨将是 阐明精神分裂症的神经生物学成分。研究中心 涉及临床和临床前研究，描述 精神分裂症的神经生物学脑异常及其作用 精神病药物。通过使用这个研究中心，科学家们将 合作在解剖学、免疫细胞化学领域研究这些问题 分子神经生物学、生化、神经生理学、临床和 行为水平。 主要研究两个主题：1)成人的脑异常 精神分裂症患者和胎儿精神分裂症高危人群和2) 苯环利定(PCP)作为精神分裂症模型的设计 围绕这一模式的调查。 研究的第一条线涉及对潜力的解剖学调查。 前脑病理解剖与免疫细胞化学特征的比较 大脑的目标区域。第二个PCP研究领域涉及 PCP NMDA受体复合体在高危胎儿和成人中的研究 对患者的PET研究：精神分裂症患者的大脑与对照组的比较 滥用PCP，在MAN中开发PCP和NMDA位点的配体， 高危胎儿和成人精神分裂症患者血浆α-内啡肽水平的研究 精神分裂症患者脑组织及脑脊液的研究改建 在多巴胺中是神经递质病理学的当前理论 精神分裂症。D1和D2受体将在动物和高 胎儿和成人精神分裂症的大脑及其相互作用的风险 兴奋性氨基酸。PCP精神病的新治疗策略是 建议。

The thrust of this neuroscience research center proposal will be to elucidate neurobiological components of schizophrenia. The research center involves both clinical and preclinical investigations delineating neurobiological brain abnormalities in schizophrenia and the actions of psychotic drugs. Through the use of this center research scientists will collaborate to study these problems at the anatomical, immunocytochemical molecular neurobiological, biochemical, neurophysiological, clinical and behavior levels. Two general themes will be investigated: 1) brain abnormalities in adult schizophrenic patients and fetuses at high risk for schizophrenia and 2) phencyclidine (PCP) as a model for schizophrenia and the design of investigations around this model. The first line of research involves an anatomical survey of potential forebrain pathology comparing anatomical and immunocytochemical features of targeted areas of the brain. The second PCP research area involves the study of the PCP NMDA receptor complex in high risk fetal and adult schizophrenic brains as compared to controls, PET studies of patients abusing PCP, development of a ligand for the PCP and NMDA site in man, the study of alpha endopsychosin in high risk fetal and adult schizophrenic brains and the investigation of CSF in schizophrenic patients. Alterations in dopamine is a current theory of neurotransmitter pathology in schizophrenia. D1 and D2 receptors will be studied in animals and high risk fetal and adult schizophrenic brains along with their interaction with excitatory amino acids. Novel treatment strategies for PCP psychosis are suggested.