PET STUDY OF BIOCHEMISTRY AND METABOLISM OF THE CNS

我们建议检验对理解以下几个问题很重要的假设 以局部功能障碍为特征的脑部疾病 涉及脑血流、新陈代谢、氨基酸利用的改变， 或神经递质过程。为了实现这种正电子发射 将应用断层扫描(PET)对这些局部大脑进行量化 措施。除了那些，还将推出新的PET标记 已经有了，可以在体内测定神经递质 与多巴胺、去甲肾上腺素、5-羟色胺、 胆碱能、谷氨酸能和GABA能系统。这将是 通过一个连贯的开发流程来选择新的 放射性示踪剂正电子发射体标记形式的制备 小动物，然后是灵长类动物，发展数学模型， 以及评价人体正电子发射计算机断层扫描研究中的放射性示踪剂药代动力学。 临床研究项目由负责的科学核心提供支持 用于回旋加速器、化学、断层扫描、数据分析和管理 功能。预计这些努力将增进了解。 改善运动障碍患者的诊断和管理 功能、亨廷顿病、帕金森病、脑瘤和 癫痫。

We propose to test hypotheses important to the understanding of several cerebral disorders which are characterized by regional dysfunctions involving altered cerebral perfusion, metabolism, amino acid utilization, or neurotransmitter processes. To accomplish this positron emission tomography (PET) will be applied to quantify these local cerebral measures. New PET markers will be introduced, in addition to those already available, to permit in vivo determination of neurotransmitter processes associated with dopaminergic, noradrenergic, serotonergic, cholinergic, glutaminergic, and GABAergic systems. This will be accomplished by a cohesive development process for selection of new radiotracers, preparation in positron-emitter labeled form, evaluation in small animals and then in primates, development of mathematical models, and assessment of radiotracer pharmacokinetics in human PET studies. Clinical research projects are supported by scientific cores responsible for cyclotron, chemistry, tomography, data analysis and administrative functions. It is expected that these efforts will enhance understanding and improve diagnosis and management of patients with disorders of motor function, Huntington's disease, Parkinson's disease, brain tumors, and epilepsy.