CBF AND METABOLISM IN STROKE AND SHOCK

该计划项目的主要目标可以分为三个主要方面 调查领域a)审查在以下方面的重要因素 缺血性损伤过程中不可逆性脑缺血损伤的发生 本身和在再灌流阶段，b)检查潜力 可能对预后产生有利影响的干预措施 缺血事件，以及c)研究或正常脑功能，调节 脑血流和新陈代谢，以及发生在 这些在缺血条件下的过程会影响大脑。 此应用程序中的项目通过其关注点紧密相关 为了更好地理解大脑功能的正常控制， 缺血侮辱引起的这些功能的改变 对大脑来说，导致大脑损伤的因素产生和 发展防止这种损害的手段。我们拥有的技术 我们的处理方式允许用户从 亚细胞水平，到中风的动物模型，到人类的临床研究。 基础科学家和临床研究人员在这方面的密切互动 计划项目允许从亚细胞研究中获得信息 和动物模型水平应用于临床情况和 相反，临床上重要的问题可以通过 基础科学家可以使用的工具。

The major goals of this program project can be divided into three main areas of investigation a) an examination of the factors important in the development of irreversible ischemic damage both during the ischemic insult itself and during the reperfusion phase, b) an examination of potential interventions which may favorable influence the outcome following an ischemic event, and c) studies or normal cerebral function, regulation of cerebral blood flow and metabolism, and the abnormalities that occur in these processes in ischemic conditions affecting the brain. The projects in this application are closely inter-related by their focus on an attempt to better understand the normal control of cerebral function, the alterations that occur in those functions produced by ischemic insults to the brain, the factors responsible for the cerebral damage produced and the development of means to prevent that damage. The techniques we have at our disposal allow use to look at these inter-related problems from the subcellular level, to animal models of stoke, to clinical studies in man. The close interaction of basic scientists and clinical researchers in this program project allows information obtained from studies at the subcellular and animal model levels to be applied to the clinical situation and conversely problems of clinical importance can be explored rapidly with the tools available to the basic scientists.