RENAL LESIONS IN THE ABLATION MODEL--ROLE OF GROWTH FACTORS

在大鼠肾大部切除，所谓的消融模型导致 以慢性肾脏为表现的进行性肾损害 失败了。我们推测进行性肾小球病变是 由于早期肾小球驻留细胞周转率增加。这 导致肾小球异常生长，肾小球增多 可使用形态测量测量的体积。我们已经表演了 用~3H胸腺嘧啶核苷进行放射自显影，发现早在两天前 肾次全切除后，肾小球增多。 有丝分裂指数以及形成细胞的周转率的增加 动脉壁。这些发现表明，细胞的调节失调 生长是肾小球硬化发展的早期事件。

A subtotal nephrectomy in rats, the so called ablation Model leads to a progressive destruction of the kidney with manifestations of chronic renal failure. We have postulated that the progressive glomerular lesions were due to an early increase in the turnover of glomerular resident cells. This leads to an abnormal glomerular growth, with an increase in the glomerular volume detectable using morphometric measurements. We have performed autoradiographies with 3H Thymidine and found that as early as two days following the subtotal nephrectomy there was an increase in the glomerular mitotic index as well as an increase in the turnover of the cells forming the arterial wall. These findings suggest that a dysregulation of cell growth is an early event in the development of glomerulosclerosis.