BIOACCUMULATION OF ENVIRONMENTAL CARCINOGENS--METHODOLOGY AND CHARACTERIZATION

来自众多研究的证据支持这一理论--人类 癌症和呼吸道疾病可由环境因素引起 污染。不同地区之间有很好的相关性。 癌症和呼吸系统疾病的发病率以及高水平的 由于空气污染。人们怀疑，即使是中等水平的空气 污染会增加有害健康影响的风险。 大气颗粒物中有机成分的生物检测 显示出诱变和致癌活性。然而，还有很多 试图将特定的健康影响归因于空气的不确定性 由于环境、暴露和环境的变化而造成的污染 人口。一项研究表明，中国的大气污染物 人体将为这一理论提供直接证据。 该项目的目的是确定有机大气 污染物可以在脂肪组织中沉积和积累。分析性 能够检测广谱化合物的方法学将 首先对气体样品、颗粒样品和 脂肪组织。两个地点的空气，每个地点都有一只猴子 殖民地，将随着时间的推移而表现出特征。其中一个地点相对来说 没有污染，而另一个有相当高的空气水平 污染。空气中发现的化合物之间的相关性 样本和脂肪组织中的样本可以提供直接证据 环境化合物可能会影响人类健康。

Evidence from numerous studies support the theory that-human cancers and respiratory illnesses can be caused by environmental pollution. There is a good correlation between regions with a high incidence of cancer and respiratory illnesses and high levels of air pollution. It is suspect that even moderate levels of air pollution can increase the risk of detrimental health effects. Biotesting of the organic fraction of atmospheric particulate has shown mutagenic and carcinogenic activity. However there is much uncertainty in trying to attribute specific health effects to air pollution due to variations in environment, exposure and the population. A study which could show atmospheric pollutants in the human body will lend direct evidence to the theory. The purpose of this project is to determine if organic atmospheric pollutants can deposit and accumulate in lipid tissues. Analytical methodology capable of detecting a broad spectrum of compounds will first be optimized for gaseous samples, particulate samples and lipid tissues. The air at two locations, each the site of a monkey colony, will be characterized over time. One site is relatively pollution free while the other has significant levels of air pollution. Correlation between the compounds found in the air samples and those in the lipid tissues could give direct evidence that environmental compounds could affect human health.