MECHANISMS OF HETEROGENEITY IN THE LUNG

此提案是对我们的计划进行竞争性更新的请求 项目这项正在进行的研究的下一阶段将解决 影响肺异质性的机制。 上一个方案涉及的机制和补偿， 限制通过肺循环流动。第一焦点 是关于肺血流受限的原因有研究表明 ADEMD形成机制、缺氧性肺血管收缩和 血栓性阻塞第二个重点是补偿 肺血流受限，特别是支气管的作用 循环，以及对右心压升高的系统反应。 在此基础上，本方案的重点是机制 肺通气和灌注的不均匀性。七个项目 并提出了三个核心，既解决区域内问题， 异质性的区域间机制。这些项目涉及 通气或灌注分开，两者的匹配，因为它 影响气体交换并影响水肿形成。 该方法是多学科的，调查人员接受了以下方面的培训： 医学，生理学，麻醉学，生物工程，形态学， 工程学和放射学这是二十年来人们对 肺生理学和医学与 investigators.该计划旨在支持其他研究， 特别是在ARDS和肺血管疾病中， 在这个机构。建议的优点包括： 许多学科的整合，这组的生产力， 研究人员和采用新的实验方法， 成像、形态重建和分形评价 异质性

This proposal is a request for a competitive renewal of our Program Project. The next phase of this ongoing research will address the mechanisms which affect heterogeneity in the lung. The previous program dealt with the mechanisms of, and compensations for, restrictions to flow through the pulmonary circulation. The first focus was on causes of pulmonary blood flow restriction. There were studies of mechanisms of ademd formation, hypoxic pulmonary vasoconstriction and thrornbotic obstruction. The second focus was on cornpensations for pulmonary blood flow restriction, particularly the role of the bronchial circulation, and the systernic response to a raised right heart pressure. Building on this,.the focus of the present program is on the mechanisms of heterogeneity of ventilation and perfusion in the lung. Seven projects and three cores are proposed which address both intraregional and interregional mechanisms of heterogeneity. The projects deal either with ventilation or perfusion separately, the matching of the two as it affects gas exchange and influences on edema formation. The approach is multidisciplinary, with investigators trained in medicine, physiology, anesthesiology, bioengineering, morphology, engineering and radiology. It is a result of two decades of interest in pulmonary physiology and medicine and .collaboration between the investigators. The program is designed to support other research, particularly in ARDS and pulmonary vascular disease, which is proceeding at this institution. The strengths of the proposal include the integration of many disciplines, the productivity of this group of investigators and the adoption of new experimental approaches using imaging, morphological reconstruction and fractal evaluation of heterogeneity.