BEHAVIORAL PHARMACOLOGY AND TOXICOLOGY

行为药理学项目的主要目的是阐明 （a）谷氨酸介导的 皮质纹状体系统和相关的解剖学系统和（B）多巴胺能 系统，包括黑质纹状体系统，以及 兴奋剂和神经安定药。与这一主要目标相关的有几个方面： 相关目标：1。“AA 2”或“AA 3”的功能效应的阐明 使君子酸兴奋性氨基酸受体 兴奋剂、可能具有抗惊厥作用的化合物和酒精 戒断2.寻找更有效的AA2受体拮抗剂。 3.突触后去神经支配的假设非特异性研究 中枢神经系统的超敏反应4. CNS效应研究 含硫的氨基酸。这些研究的最终目的是 加强我们对精神抑制剂作用方式的理解， 也可能是精神分裂症的脑功能障碍次要目的是 为了增强我们对兴奋剂作用机制的理解， 酒精成瘾，开发具有潜在效用的化合物， 兴奋剂过量、精神分裂症和癫痫发作的急性治疗 疾病，并了解可塑性的可能形式， 皮质纹状体系统

The project on Behavioral Pharmacology is primarily aimed at elucidating interactions between functions of (a) the glutamate-mediated corticostriatal system and related anatomical systems and (b) dopaminergic systems, including the nigrostriatal system, and functional effects of stimulant and neuroleptic drugs. Related to this primary aim are several related goals: 1. Elucidation of the functional effects of the "AA2" or quisqualic acid excitatory amino acid receptor, in relationship to stimulants, compounds with possible anticonvulsant effects, and alcohol withdrawal. 2. A search for more effective antagonists of the AA2 receptor. 3. Studies on the hypothetical non-specificity of postsynaptic denervation supersensitivity in the central nervous system. 4. Studies of CNS effects of sulfur-containing amino acids. The ultimate purpose of these studies is to enhance our understanding of the mode of action of neuroleptics and possibly brain dysfunction in schizophrenia as well. Secondary purposes are to enhance our understanding of mechanisms of stimulant drug effects, alcohol addiction, to develop compounds with potential utility for the acute treatment of stimulant overdose, schizophrenia, and seizure disorders, and to understand the possible forms of plasticity in the corticostriatal system.