CHEMICAL ANTIDEPRESSANT EFFECTS ON BODY MASS AND BODY COMPOSITION IN HAMSTERS

据报道，抗抑郁药物会降低静息代谢率。 并改变抑郁症患者的体重。体重增加可能是 部分与代谢率下降有关。能量的变化 慢性药物治疗后的预算可能与 抗抑郁药物的行为激活作用。 A型单胺氧化酶(MAO)的慢性抑制作用 抗抑郁药物clorgyline改变叙利亚仓鼠的身体质量。这 体重的变化主要是由于体脂含量的减少。 在目前的研究中，我们观察到clorgyline减少了氧气。 叙利亚人的体温和食物消费水平 仓鼠。我们的工作假设是Clorgyline诱导的 耗氧量和温度与食物的减少有关 长期服药所伴随的摄入量。我们的数据是 与MAO抑制降低 下丘脑的温度设定值。

Antidepressant drugs are reported to decrease in the resting metabolic rate and alter body mass of depressed patients. Increased body mass may be partly related to the decrease in metabolic rate. The change in energy budgeting that follows chronic drug treatment may be related to the behavior activating effects of antidepressant drugs. Chronic inhibition of type A monoamine oxidase (MAO) with the antidepressant drug clorgyline alters body mass in Syrian hamsters. This change in body mass was primarily due to an decrease in body lipid content. In the current studies we observed that the clorgyline decreases oxygen consumption the level of body temperature and food consumption in Syrian hamsters. Our working hypothesis is that the clorgyline-induced decrease in oxygen consumption and temperature are related to the diminished food intake that accompanies chronic drug administration. Our data are consistent with the interpretation that MAO inhibition decreases the temperature set-point of the hypothalamus.