PSYCHOBIOLOGY/GENETICS/TREATMENT OF ANXIETY DISORDERS

该计划项目赠款是一个多学科的尝试，以处理 焦虑症的复杂性 我们原来的 努力验证DSM-III在生理学方面的疾病， 对挑衅的反应，和家庭研究，现在扩展到处理 同时也涉及到跨部门和发展的复杂问题， 共病 我们的团队现在包括Rachel Gittelman Klein和Myrna Weissman; 临床发展和纵向研究专家 样本、家庭研究和流行病学样本。 雷切尔·克莱因将对黑猩猩的后代进行系统的研究， 惊恐障碍、社交恐怖症、广场恐怖症、单纯性 恐惧症和正常人 Myrna Weissman将研究已经收集的ECA数据， 现在可以进行全面的跨站点分析，从而应用 流行病学聚集变量和风险因素， 症状验证的问题 杰克·戈尔曼关于换气过度和二氧化碳的项目资助 恐慌症的敏感性被这一补助金放大， 包括社交恐惧症和强迫症。 三十五 百分之一百的二氧化碳挑战允许进一步研究 惊恐患者的二氧化碳剂量反应曲线 障碍、社交恐惧症、强迫症和正常 对照 为了控制认知和期望效应， 将与气道阻力增加进行比较。 家庭研究将继续探讨科摩罗问题， 惊恐障碍，社交恐怖症，广场恐怖症，单纯性 恐惧症和两类正常人（熟人和亲戚的 普通的熟人）。 一级亲属的盲法随访 焦虑症将提供关于焦虑症发作的信息， 这一高风险群体以及未经治疗的自然史 病人 将对选定的家系进行DNA分析 与James Gusella和Jurg Ott合作。

This Program Project Grant is a multidisciplinary attempt to deal with the complexities of the anxiety disorders. Our original effort to validate the DSM-III disorders in terms of physioloqy, response to provocation, and family study, is now extended to deal also with the complex issue of cross sectional and developmental co-morbidity. Our team now includes Rachel Gittelman Klein and Myrna Weissman; experts in the developmental and longitudinal study of clinical samples, family studies, and epidemiological samples. Rachel Klein will pursue the systematic study of the offspring of patients with panic disorder, social phobia, agoraphobia, simple phobia and normals. Myrna Weissman will study the already gathered ECA data, which is now ready for complete cross-site analyses, thus applying the variables of epidemiological aggregation and risk factors to the problem of syndromal validation. Jack Gorman's project grant on hyperventilation and carbon dioxide sensitivity in panic disorders is amplified by this grant to include social phobics and obsessive compulsives. Thirty-five percent carbon dioxide challenges allow for yet further study of the carbon dioxide dose response curve in patients with panic disorder, social phobia, obsessive compulsive disorder and normal controls. To control for cognitive and expectation effects a comparison with increased airway resistance will be conducted. The family study will pursue the issue of comorbidity and heterogeneity in panic disorder, social phobia, agoraphobia, simple phobia and two classes of normals (acquaintances and relatives of normal acquaintances). Blind followup of first degree relatives of anxiety disorders will provide information concerning onset of this high risk group as well as the natural history of untreated sick people. DNA analyses of selected pedigrees will be conducted in collaboration with James Gusella and Jurg Ott.