CENTER FOR CLINICAL RESEARCH IN EPILEPSY

这项中心拨款续期代表了一种多学科的方法。 用于癫痫的临床研究。这里包括的项目有 专门针对复杂部分性癫痫发作的研究 以及他们的药物管理。项目1是应用 统计模型对新药临床评价的实际应用 抗癫痫药物(AED)。项目2关注的是 为AED研究开发新的统计方法。项目 3检测人脑中AED的浓度-反应关系 在癫痫手术中从病人身上取出。项目4 描述和搜索心因性癫痫发作的相关因素。 项目5将检查有毒物质形成的确定因素 丙戊酸代谢产物与项目6强化效应 对癫痫康复的干预。三核管理 协调整个中心的活动，并提供基本的 神经病学的多学科临床研究支持， 神经心理学、护理、社会工作和职业 康复。核心生物统计提供统计数据 会诊和数据分析，并支持患者群体 作为所有需要临床研究的研究的资源的数据库 患者以及流行病学研究。核心计算机 设施支持所有统计分析和患者 人口数据库。 这项工作的主要部分将在区域癫痫研究所完成 中心，一个多学科的临床研究中心，专注于 自1975年以来一直活跃的癫痫。那个中心带来了 联合对癫痫感兴趣的调查人员，患者 癫痫的疑难发作问题和治疗方法， 这为临床研究提供了机会。这也已经 为一系列临床研究和研究提供了基础 癫痫方面的培训计划超出了本提案的范围。这个 该中心的总体目标，以及这次中心拨款续签是为了 继续通过多项措施解决癫痫的主要问题 维度方法结合了广泛的临床 有雄厚的核心支撑基础的研究。

This center grant renewal represents a multidisciplinary approach to clinical research in epilepsy. Projects included here are specifically aimed toward research into complex partial seizures and their drug management. Project 1 is the application of statistical models to actual clinical evaluations of new antiepileptic drugs (AED). Project 2 is concerned with the development of new statistical methods for AED studies. Project 3 examines AED concentration-response relationship in human brain removed from patients during epilepsy surgery. Project 4 characterizes and searches for correlates of psychogenic seizures. Project 5 will examine determinates of the formation of toxic metabolites of valproic acid and Project 6 the effects of intensive intervention on epilepsy rehabilitation. Three Core Administration coordinates overall center activities and provides basic multidisciplinary clinical research support in neurology, neuropsychology, nursing, social work, and vocational rehabilitation. Core Biostatistics provides statistical consultation and data analysis, and supports the Patient Population Data Base as a resource for all studies requiring clinical research patients as well as epidemiological studies. Core Computer facilities support all statistical analysis and the Patient Population Data Base. The major part of this work will be done at the Regional Epilepsy Center, a multidisciplinary clinical research center focusing on epilepsy that has been active since 1975. That center brings together investigators interested in epilepsy, patients with difficult seizure problems and therapeutic approaches for epilepsy, that provide opportunities for clinical research. This has also provided the basis for a range of clinical research and research training programs in epilepsy beyond those of this proposal. The overall goal of that center, and this center grant renewal is to continue to address major problems in epilepsy through a multi- dimensional approach which combines a broad range of clinical research with a strong base of core support.