Defining the roles of platelet protease-activated receptors in thrombosis

不适当的血液凝块形成是大多数心脏病发作和一些中风的原因。血小板是造成这种凝块的血细胞。我们对控制血小板进入血栓的信号感兴趣，因为干扰这一过程的药物可能有效地抑制不想要的血栓形成。我们的研究确定了血小板信号的重要性，这将为阻断这类信号作为抗凝血剂的可能有效性提供强有力的线索。

Inappropriate blood clot formation is the cause of most heart attacks and some strokes. Platelets are the blood cells responsible for such clots. We are interested in the signals which control platelet incorporation into clots because drugs that interfere with this may be effective at inhibiting unwanted clot formation. Our studies determining the importance of platelet signals will provide strong clues to the likely effectiveness of blocking such signals as anti-clotting agents.