PURCHASE OF A MOLECULAR MODELLING FACILITY

这项提案要求为该部建立一个分子模拟设施 加州大学欧文分校化学专业。该设施将包括 带附件的核心CPU(Silicon Graphics 4D/80GT工作站) 工作站、图形输出设备、数据存储和软件。这个 设施将为各种 生物有机、生物物理、生物无机、合成和物理有机 系里的研究项目。这些计划包括研究 以下领域：蛋白质、核酸的结构和功能 和低聚糖，蛋白质-核酸相互作用，分子 认识、合理药物设计、聚合物化学和总体 生物碱、甾体、神经毒素等生物活性物质的合成 和海洋天然产品。九个院系的生物医学研究计划 (五名高级教员共获得八项小灵通助学金，四名初级教员 竞争PHS支持的教职员工)将由该设施提供支持。

This proposal request for a molecular modelling facility for the Department of Chemistry, University of California, Irvine. The facility will consist of a core CPU (Silicon Graphics 4D/80GT workstation) with accessory workstations, graphics output devices, data storage and software. The facility will provide necessary computational support for a variety of bioorganic, biophysical, bioinorganic, synthetic and physical organic research programs in the Department. These programs include research in the following areas: the structure and function of proteins, nucleic acids and oligosaccharides, protein-nucleic acid interactions, molecular recognition, rational drug design, polymer chemistry, and the total synthesis of bioactive agents including alkaloids, steroids, neurotoxins and marine natural products. Biomedical research programs of nine faculty (five senior faculty holding a combined eight PHS grants and four junior faculty competitive for PHS support) will be supported by the Facility.