VARIAN VXR 500 S SUPERCONDUCTING HIGH RESOLUTION FT NMR

波士顿学院化学系要求40万美元， 购买500 MHz Varian VXR-500 NMR光谱仪系统， 用于生化和化学研究。 项目将受益于 获得这一仪器包括研究（i）酶机制 使用位点特异性突变体;（ii）修饰的核酸及其 与DNA结合蛋白的相互作用;（iii） 溶液;（iv）模型膜及其与水溶性 脂肪酶;（v）不常见生物体中的细胞代谢;（vi）apoB肽 以及它们与脂质的相互作用;（vii）合成化合物， 化学疗法的潜力;（viii）用于催化 键形成;（ix）几种抗生素的合成路线;（x） 电子效应对芳香族分子NMR参数的影响;和（Xi）金属 核苷酸复合物。 其中许多项目将得到 更大的光谱色散和更高的灵敏度的500超过 目前可用的300 MHz机器。 几个类别的结构研究 需要这样一个高场光谱仪的2-D方法。

The Chemistry Department of Boston College is requesting $400,000 toward the purchase of a 500 MHz Varian VXR-500 NMR Spectrometer system to be used for biochemical and chemical research. Projects which will benefit from the acquisition of this instrument include studies of (i) enzyme mechanisms using site-specific mutants; (ii) modified nucleic acids and their interactions with DNA bindingproteins; (iii) hormone peptide structures in solution; (iv) model membranes and their interactions with water-soluble lipases; (v) cellular metabolism in unusual organisms; (vi) apoB peptides and their interactions with lipids; (vii) synthetic compounds with potential for chemotherapy; (viii) synthetic active sites for catalysis of bond formation; (ix) synthetic routes to several antibiotics; (x) electronic effects on NMR parameters of aromatic molecules; and (xi) metal complexes of nucleotides. Many of these projects will be aided by the greater spectral dispersion and higher sensitivity of the 500 over the presently available 300 MHz machine. Structural studies of several classes of molecules require such a high-field spectrometer for 2-D methodologies.