DATA COORDINATING CENTER /NATURAL HISTORY OF AIDS

CAMAC的总体目标是： (a)提供生物统计学支持，以更好地了解 HIV感染的自然史 (b)进行适当的生物统计学分析， 确定风险因素，并采取适当的干预措施， 疾病的传播， (c)生物统计学有助于描述任何生物或 环境因素，将改变自然历史， 疾病（例如，限制或加速发病率， 与感染相关的死亡率）。 CAMAC研究的具体目标是： (1)提供生物统计学支持， 男性同性恋人群中HIV感染史 分析人口统计学，社会文化和行为 自我报告的数据，并通过统计相关的数据与 体格检查结果，HIV抗体状态，免疫学 以及血液化学和血液学参数， 其他病毒的抗体。 (2)统计学估计疾病进展率， 通过比较实验室结果（HLA型，CBC， SMA-12），免疫学参数（流式细胞术），物理 检查，神经精神评估和机电 结果（EEG，EKG，MRI，CAT，神经传导研究， 放射学发现）与行为事件。 (3)统计估计1999年至2000年期间 性同性恋者的行为 这可能改变血清转化率。 (4)统计估计合并病毒的性质和程度 性活跃的同性恋男子感染。

The general objectives of the CAMAC are: (a) To provide the biostatistical support to better understand the nature history of HIV infection (b) To conduct the appropriate biostatistical analyses to determine the risk factors, and appropriate interventions to limit the spread of the disease and to (c) biostatistically help characterize any biologic or environmental factors which will alter the natural history of the disease (e.g., either limit or accelerate the morbidity and mortality associated with infection) in this population. The specific objectives of the CAMAC study are: (1) To provide the biostatistical support to study the natural history of HIV infection among a population of homosexual men who analyzing the demographic, socio-cultural and behavioral self-report data and by statistically correlating this data with physical examination findings, HIV antibody status, immunologic and blood chemistry and hematology parameters and the presence of antibodies to other viruses. (2) To statistically estimate the rate of disease progression of infection by comparing laboratory findings (HLA-type, CBC, SMA-12), immunologic parameters (by flow cytometry), physical examinations, neuropsychiatric evaluations and electromechanical findings (EEG, EKG, MRI, CAT, nerve conduction studies, radiographic findings) with behavioral events. (3) To statistically estimate the rate of seroconversion among sexually homosexual men as well as determine those behaviors which may alter the rate of seroconversion. (4) To statistically estimate the nature and extent of co-virus infections among sexually active homosexual men.