ELECTRON SPIN RESONANCE SPECTROMETER

请拨资金购买Bruker ESP 300-10/7 ESR光谱仪。这台光谱仪将显著提高 俄勒冈大学化学系的电子自旋共振能力。 目前，该部内有一名瓦里安·E-3 分光计，购买于1966年(主要用于教学 仪器)，以及1981年购买的瓦里安E线光谱仪。 格里菲斯教授的E线光谱仪被大量使用 并且不能支持这里提议的所有项目。在……里面 此外，该仪器正变得越来越困难和昂贵 因为瓦里安不再提供零件，配件， 或者服务。 所要求的ESP 300-10/7光谱仪是最先进的， 功能齐全、操作方便的仪器现已上市。这个 光谱仪及所需配件将广泛使用 各种与健康相关的研究项目。具体地说，这些 包括： 基纳教授：新型顺磁分子的表征 专为生物物理研究而设计，并用于增强对比 用于全身核磁共振成像的试剂。 Branchaud教授：使用自由基探针研究酶 反应。 芬克教授：电化学和光化学研究 辅酶介导的电子转移反应的性质 B12。 格里菲斯教授：自旋标记脂质的ESR研究 了解脂质与蛋白质的相互作用。 冯·希佩尔教授：对E。 利用氮氧化物自旋表达的转录终止蛋白Rho 标有赛斯-202的。 其他拟议的研究包括： 佩奇教授：顺磁轨道对称性变化的研究 溶胶-凝胶法合成多元氧化物中的离子。 里士满教授：ESR作为非晶态表面缺陷的探针 硅和锗。 泰勒教授：19电子有机金属的表征 复合体。

Funds are requested for the acquisition of a Bruker ESP 300-10/7 ESR spectrometer. This spectrometer will significantly improve the ESR capabilities of the University of Oregon Chemistry Department. Currently there exist within the Department a Varian E-3 spectrometer, purchased in 1966 (used primarily as a teaching instrument), and a Varian E-line spectrometer acquired in 1981. The E-line spectrometer is used heavily by Professor Griffith's group and cannot support all of the projects proposed here. In addition, the instrument is becoming more difficult and expensive to maintain because Varian no longer provides parts, accessories, or service. The requested ESP 300-10/7 spectrometer is the most advanced, versatile and easily operated instrument available today. The spectrometer and requested accessories will be put to use in a wide variety of health-related research projects. Specifically, these include: Prof. Keana: Characterization of novel paramagnetic molecules designed for biophysical studies and for use as contrast enhancing agents for whole body magnetic resonance imaging. Prof. Branchaud: The use of radical probes to investigate enzyme reactions. Prof. Finke: An electrochemical and photochemical investigation of the nature of electron transfer reactions mediated by Coenzyme B12. Prof. Griffith: ESR studies of spin labeled lipids directed at understanding lipid-protein interactions. Prof. von Hippel: A study of the mechanism of action of the E. coli transcription termination protein rho using nitroxide spin labeled Cys-202. Other proposed research includes: Prof. Page: A study of the site symmetry changes of paramagnetic ions in the sol-gel synthesis of multicomponent oxides. Prof. Richmond: ESR as a probe of surface defects in amorphous silicon and germanium. Prof. Tyler: Characterization of nineteen-electron organometallic complexes.