EFFECT OF AMINOPHYLLINE ON POST-ISCHEMIC EDEMA AND BRAIN INJURY

目的观察氨茶碱对脑缺血后水肿及脑损伤的影响。 在接受大脑中动脉（MCA） 闭塞1小时。 氨茶碱22.8 mg/kg给药 在MCA闭塞解除时输注15分钟 导致反应性充血的抑制，并被证明具有 对缺血后的发展有明确的有益作用， 水肿和脑损伤。 使用氨茶碱的动物没有表现出 血脑屏障对蛋白质示踪剂的破坏， 当处死时，缺血区域无明显水肿3 在MCA闭塞解除后24小时。 此外，猫 氨茶碱治疗显示， 损伤后3天和14天进行组织学研究， 再循环 因此，我们的研究表明， 氨茶碱有可能被考虑用于治疗 在某些临床条件下。

Effect of aminophylline on post-ischemic edema and brain injury was studied in cats subjected to the middle cerebral artery (MCA) occlusion for 1 hour. Administration of aminophylline 22.8 mg/kg infused for 15 minutes at the time of release of MCA occlusion resulted in suppression of reactive hyperemia and proved to have an unequivocal beneficial effect on development of post-ischemic edema and brain injury. The animals with aminophylline showed no breakdown of the blood-brain barrier to protein tracers and showed no significant edema in the ischemic regions, when sacrificed 3 hours after release of MCA occlusion. Also, cats with aminophylline treatment revealed significantly milder ischemic injury when studied histologically at 3 and 14 day periods after recirculation. Our studies thus demonstrate a marked beneficial effect of aminophylline with a potential to be considered for treatment of patients in certain clinical conditions.