MICROBIAL ECOLOGY & ITS RELATION TO DENTAL DISEASE

该提案提出了一个广泛的计划，其目标是提供 为了更好地了解 龋齿的病因和发病机制以及各种形式的 牙周病，并制定合理的方法， 他们的控制。 该计划整合了调查人员的努力 在微生物学，动物实验， 电子显微镜、营养学、牙周病学和临床 牙科，并代表正在进行的研究的延伸。 的 具体目标包括努力制定和完善方法， 用于研究重要的口腔细菌， 牙齿致病菌，占，或影响他们的 毒性 其他目的涉及阐明参数， 影响突出口语的传播和习得 细菌 特别强调的是， 环境因素影响的殖民化 潜在重要的牙齿致病菌。 包括的是 饮食成分影响的研究，局部应用 氟化物、多形核白细胞及其产物， 某些抗体，口内定位，和纤维连接蛋白对口腔 微生物定植

This proposal presents a broad program whose goal is to provide key pieces of basic information required to better understand the etiology and pathogenesis of dental caries and various forms of periodontal disease, and to formulate rational approaches for their control. The program integrates the efforts of investigators experienced in the areas of microbiology, animal experimentation, electron microscopy, nutrition, periodontology and clinical dentistry, and represents an extension of on-going studies. The specific aims include attempts to develop and refine methodology for studying important oral bacteria, and studies of the properties of odontopathic bacteria which account for, or influence their virulence. Other aims relate to elucidating parameters which influence the transmission and acquisition of prominent oral bacteria. Special emphasis is being devoted to studies of host and environmental factors which affect the colonization of potentially- important odontopathic bacteria. Included are studies of the influence of dietary components, topically-applied fluorides, polymorphonuclear leucocytes and their products, certain antibodies, intraoral location, and fibronectin on oral microbial colonization.