ORGAN TRANSPLANTATION IN ANIMALS AND MAN

这是一份申请延续项目资助的申请书。最基本的 总体目标是：(A)分析和隔离临床问题 参与器官移植并准确记录临床实验室 关联性。(B)根据现有数据组织临床试验，以解决 临床问题。(C)为这些问题提出试验性的解决办法 最终可以应用于临床问题。 在这些目标中，有四个基本的临床目标 我们所有的项目都是在这种移植下组织起来的。目标1：实现 防止宿主破坏器官。这包括组织分型的问题， 与排斥反应相关的配型和免疫抑制，以及 复发性疾病。目的2：对抗感染。目标3：最大化 康复。目标4：保持患者和器官处于最佳状态 移植前和移植期间。这包括血液透析的问题， 器官提取和储存。

This is an application for continuation of a program project grant. The basic overall objectives have been to: (a) Analyze and isolate the clinical problems involved in organ transplantation and precisely document clinical-laboratory correlations. (b) Organize clinical trials based on available data to solve clinical problems. (c) Generate experimental solutions to these problems which can ultimately be applied to the clinical problem. Within these objectives, there are four essential aims in clinical transplantation under which all our projects have been organized. Aim 1: To Prevent Organ Destruction by host. This includes problems of tissue typing, matching, and immunosuppression related to rejection as well as problems of recurrent disease. Aim 2: To Counteract Infection. Aim 3: To Maximize Rehabilitation. Aim 4: To Maintain Patient and Organ in Optimal Condition Prior to and During Transplantation. This includes problems of hemodialysis, organ retrieval, and storage.