Mood, mother, and child: The psychobiology of dyadic resilience

情绪、母亲和孩子：二元复原力的心理生物学

• 批准号: 9979927
• 负责人: William Roger Mills-Koonce
• 金额: $ 61.69万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-07 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9979927
• 关键词: 5 year old; Affect; Anxiety; Anxiety Disorders; Blinded; Child; Child Development; Child Rearing; Cognitive; Development; Ensure; Epigenetic Process; Executive Dysfunction; Exhibits; Exposure to; Follow-Up Studies; Genetic; Genetic Variation; Genotype; Goals; Growth; Health; Heterogeneity; Impaired cognition; Impairment; Individual; Infant; Internet; Intervention; Late pregnancy; Life; Longitudinal cohort study; Measures; Mediating; Mediator of activation protein; Mental Depression; Mission; Modeling; Moods; Mothers; National Institute of Child Health and Human Development; Nose; OXT gene; Outcome; Oxytocin; Participant; Pathway interactions; Phenotype; Physiology; Placebos; Play; Postpartum Period; Predictive Factor; Psychopathology; Public Health; Relapse; Research; Risk; Role; Sampling; School-Age Population; Trier Social Stress Test; Work; boys; caregiving; emotion regulation; executive function; experience; externalizing behavior; girls; high risk; hypothalamic-pituitary-adrenal axis; indexing; intergenerational; maternal anxiety; maternal depression; novel strategies; peripartum depression; prevent; protective factors; psychobiologic; psychobiology; psychosocial; psychosocial adjustment; resilience; sex; stress reactivity; transmission process

ABSTRACT: MOOD, MOTHER AND CHILD: THE PSYCHOBIOLOGY OF DYADIC RESILIENCE Perinatal depression (PND) affects more than 400,000 mother-infant dyads in the US each year, with devastating consequences. Mothers with PND exhibit reduced sensitivity to infant needs, increasing infant risk for impaired emotional regulation and insecure attachment. These dysregulated interactions in the first year of life are associated with impaired cognitive and socioemotional development, including child psychopathology and impaired executive function (EF). Mothers who experience PND are more likely to have continuing or relapsing depression and anxiety disorders, conferring further risk. Nevertheless, despite exposure to PND, some dyads emerge intact. The long-term goal of this research is to identify the psychobiological underpinnings of resilience among mother-child dyads exposed to PND and longer-term maternal depression and anxiety trajectories (MDATs). The objectives of this proposal are to characterize MDAT heterogeneity during the first 5 years of the child’s life, to identify mediators that explain the mechanisms through which MDATs influence child outcomes, and identify moderators that may serve as intervention points for promoting dyadic resilience. We will leverage an existing pool of participants in the Mood, Mother and Infant (MMI) study (R01HD073220, mmi.web.unc.edu, PI Stuebe), an ongoing longitudinal cohort study that we have led of mother-infant dyads (N=222) who have been extensively phenotyped during the first postpartum year. Our central hypothesis is that oxytocin plays a central role in dyadic development, indexed by associations between OT psychobiology, genetics and epigenetics and both MDATs and child development outcome. The rationale for this work is that our findings will inform targeted interventions to facilitate resilience and diminish the sequelae of maternal depression. We will accomplish the objective of our application by pursuing the following specific aims via an MMI follow-up study, the Mood, Mother and Child (MMC) study: 1) Elucidate the role of OT in the maternal psychobiological underpinnings of MDATs and parenting behavior, including effects of exogenous oxytocin (OT) on HPA axis reactivity; 2) Determine psychosocial mediators and moderators of associations between MDATs and child developmental outcome; and 3) Determine the extent to which child OXT and OXTR genotype moderates associations between MDATs, sensitivity, attachment quality, and developmental outcome; quantify the extent to which child epigenetic changes in OT and OXTR mediate associations between MDATs and developmental outcome. The expected outcomes of this work will be the determination of both predictive and protective factors for mother-infant dyads affected by depression and anxiety, laying the groundwork for novel approaches to promote resilience. Such results will have a positive impact by informing interventions to prevent intergenerational transmission of depression and anxiety.

摘要：情绪、母亲和孩子：二元弹性的心理生物学 围产期抑郁症（PND）每年影响美国超过40万对母婴， 毁灭性的后果患有PND的母亲对婴儿需求的敏感性降低，增加了婴儿的风险 情绪调节受损和不安全的依恋这些失调的相互作用在第一年的 生活与认知和社会情感发育受损有关，包括儿童精神病理学 执行功能受损（EF）。经历PND的母亲更有可能持续或 抑郁症和焦虑症的复发，带来了进一步的风险。然而，尽管暴露于PND， 一些二分体完整地出现。这项研究的长期目标是确定心理生物学 暴露于PND和长期母亲抑郁症的母子二人组的弹性基础 焦虑轨迹（Anxiety Trajectories，MDAT）本提案的目的是描述MDAT异质性的特征 在儿童生命的前5年，确定解释机制的调解人， MDAT影响儿童的结果，并确定主持人，可以作为干预点，促进 二元弹性我们将利用现有的参与者库在情绪，母亲和婴儿（MMI）的研究 （R 01 HD 073220，mmi.web.unc.edu，PI Stuebe），我们领导的一项正在进行的纵向队列研究， 在产后第一年进行了广泛的表型分析的母婴二联体（N=222）。我们 中心假设是催产素在二元发展中起着中心作用， OT心理生物学，遗传学和表观遗传学以及MDAT和儿童发育结果。的理由 我们的研究结果将为有针对性的干预措施提供信息，以促进恢复力并减少 母亲抑郁症的后遗症我们将通过以下方式实现我们申请的目标 具体目标通过MMI后续研究，情绪，母亲和儿童（MMC）研究：1）阐明OT的作用 在母亲的心理生物学基础的MDAT和养育行为，包括影响 外源性催产素（OT）对HPA轴反应性的影响; 2）确定 MDAT与儿童发展结果之间的关联;以及3）确定儿童 OXT和OXTR基因型调节MDAT、敏感性、依恋质量和 发育结果;量化OT和OXTR介导的儿童表观遗传变化的程度 MDAT与发展结果之间的关系。这项工作的预期成果将是： 抑郁症影响母婴二对的预测因素和保护因素的确定， 焦虑，为新的方法奠定基础，以促进弹性。这样的结果将有积极的 通过宣传干预措施防止抑郁症和焦虑症的代际传播。