Mood, mother, and child: The psychobiology of dyadic resilience

情绪、母亲和孩子：二元复原力的心理生物学

• 批准号: 10215574
• 负责人: William Roger Mills-Koonce
• 金额: $ 59.03万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-07 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10215574
• 关键词: 5 year old; Affect; Anxiety; Anxiety Disorders; Blinded; Child; Child Development; Child Rearing; Cognitive; Development; Ensure; Epigenetic Process; Executive Dysfunction; Exhibits; Exposure to; Follow-Up Studies; Genetic; Genetic Variation; Genotype; Goals; Growth; Health; Heterogeneity; Impaired cognition; Impairment; Individual; Infant; Internet; Intervention; Late pregnancy; Life; Longitudinal cohort study; Measures; Mediating; Mediator of activation protein; Mental Depression; Mission; Modeling; Moods; Mothers; National Institute of Child Health and Human Development; Nose; OXT gene; Outcome; Oxytocin; Participant; Pathway interactions; Phenotype; Physiology; Placebos; Play; Postpartum Period; Predictive Factor; Psychopathology; Public Health; Relapse; Research; Risk; Role; Sampling; School-Age Population; Trier Social Stress Test; Work; boys; caregiving; emotion regulation; executive function; experience; externalizing behavior; girls; high risk; hypothalamic-pituitary-adrenal axis; indexing; intergenerational; maternal anxiety; maternal depression; novel strategies; peripartum depression; prevent; protective factors; psychobiologic; psychobiology; psychosocial; psychosocial adjustment; resilience; sex; stress reactivity; transmission process

ABSTRACT: MOOD, MOTHER AND CHILD: THE PSYCHOBIOLOGY OF DYADIC RESILIENCE Perinatal depression (PND) affects more than 400,000 mother-infant dyads in the US each year, with devastating consequences. Mothers with PND exhibit reduced sensitivity to infant needs, increasing infant risk for impaired emotional regulation and insecure attachment. These dysregulated interactions in the first year of life are associated with impaired cognitive and socioemotional development, including child psychopathology and impaired executive function (EF). Mothers who experience PND are more likely to have continuing or relapsing depression and anxiety disorders, conferring further risk. Nevertheless, despite exposure to PND, some dyads emerge intact. The long-term goal of this research is to identify the psychobiological underpinnings of resilience among mother-child dyads exposed to PND and longer-term maternal depression and anxiety trajectories (MDATs). The objectives of this proposal are to characterize MDAT heterogeneity during the first 5 years of the child’s life, to identify mediators that explain the mechanisms through which MDATs influence child outcomes, and identify moderators that may serve as intervention points for promoting dyadic resilience. We will leverage an existing pool of participants in the Mood, Mother and Infant (MMI) study (R01HD073220, mmi.web.unc.edu, PI Stuebe), an ongoing longitudinal cohort study that we have led of mother-infant dyads (N=222) who have been extensively phenotyped during the first postpartum year. Our central hypothesis is that oxytocin plays a central role in dyadic development, indexed by associations between OT psychobiology, genetics and epigenetics and both MDATs and child development outcome. The rationale for this work is that our findings will inform targeted interventions to facilitate resilience and diminish the sequelae of maternal depression. We will accomplish the objective of our application by pursuing the following specific aims via an MMI follow-up study, the Mood, Mother and Child (MMC) study: 1) Elucidate the role of OT in the maternal psychobiological underpinnings of MDATs and parenting behavior, including effects of exogenous oxytocin (OT) on HPA axis reactivity; 2) Determine psychosocial mediators and moderators of associations between MDATs and child developmental outcome; and 3) Determine the extent to which child OXT and OXTR genotype moderates associations between MDATs, sensitivity, attachment quality, and developmental outcome; quantify the extent to which child epigenetic changes in OT and OXTR mediate associations between MDATs and developmental outcome. The expected outcomes of this work will be the determination of both predictive and protective factors for mother-infant dyads affected by depression and anxiety, laying the groundwork for novel approaches to promote resilience. Such results will have a positive impact by informing interventions to prevent intergenerational transmission of depression and anxiety.

摘要：情绪、母亲和孩子：二元复原力的心理生物学 在美国，围产期抑郁症 (PND) 每年影响超过 40 万母婴组合，其中 毁灭性的后果。患有 PND 的母亲对婴儿需求的敏感性降低，增加了婴儿的风险 情绪调节受损和不安全的依恋。这些失调的相互作用在第一年 生活与认知和社会情感发展受损有关，包括儿童精神病理学 和执行功能（EF）受损。经历过 PND 的母亲更有可能继续或 抑郁症和焦虑症复发，带来进一步的风险。然而，尽管暴露于 PND， 一些二元体完好无损地出现。这项研究的长期目标是确定心理生物学 遭受 PND 和长期母亲抑郁的母子二人复原力的基础 和焦虑轨迹（MDAT）。该提案的目标是描述 MDAT 异构性的特征 在孩子生命的前 5 年里，找出调解因素来解释其机制 MDAT 影响儿童的成果，并确定可以作为促进儿童发展的干预点的调节因素 二元弹性。我们将利用情绪、母亲和婴儿 (MMI) 研究的现有参与者库 （R01HD073220，mmi.web.unc.edu，PI Stuebe），我们领导的一项正在进行的纵向队列研究 母婴二人组 (N=222) 在产后第一年进行了广泛的表型分析。我们的 中心假设是催产素在二元发展中发挥着核心作用，以两者之间的关联为索引 OT 心理生物学、遗传学和表观遗传学以及 MDAT 和儿童发育结果。理由 这项工作的目的是，我们的研究结果将为有针对性的干预措施提供信息，以增强复原力并减少 产妇抑郁症的后遗症。我们将通过追求以下目标来实现我们的申请目标 通过 MMI 后续研究、情绪、母亲和儿童 (MMC) 研究确定具体目标：1) 阐明 OT 的作用 MDAT 和养育行为的母亲心理生物学基础，包括 外源性催产素 (OT) 对 HPA 轴反应性的影响； 2）确定心理社会调解者和调节者 MDAT 与儿童发育结果之间的关联； 3）确定儿童的程度 OXT 和 OXTR 基因型调节 MDAT、敏感性、依恋质量和 发展成果；量化 OT 和 OXTR 中儿童表观遗传变化介导的程度 MDAT 与发展成果之间的关联。这项工作的预期成果将是 确定受抑郁症影响的母婴二人组的预测因素和保护因素 焦虑，为提高复原力的新方法奠定基础。这样的结果将会产生积极的影响 通过告知干预措施以防止抑郁和焦虑的代际传播来产生影响。