精神分裂症患者淋巴细胞中的逆转录病毒活性-猫眼课题宝

精神分裂症患者淋巴细胞中的逆转录病毒活性

批准号：

3944771

负责人：

A FEENSTRA

金额：

$0.0万

依托单位：

NATIONAL INSTITUTE OF MENTAL HEALTH

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/3944771

关键词：

RNA directed DNA polymerase Retroviridae disease human T cell lymphotropic virus type 1 human T cell lymphotropic virus type 2 human immunodeficiency virus 1 human tissue lymphocyte mental disorder diagnosis mental health epidemiology nervous system disorder diagnosis neurotropic virus schizophrenia tissue /cell culture

中文摘要

翻译

精神分裂症可能与病毒感染有关的证据

英文摘要

The evidence that schizophrenia may involve infection by a virus (or viruses) has been indirect. This evidence includes the phenomenology of schizophrenia (insofar as it may be mimicked by some viral encephalitides), epidemiological factors (including a predominance among patients with late winter/early spring births, a north-south gradient, and occasional clustering of cases), and indirect laboratory evidence (gliosis in some neuropathological studies, spinal fluid protein abnormalities, and abnormalities in cell-mediated immunity). The discovery of the human retroviruses, HTLVI, HTLVII and HIV, now also known to affect the CNS, together with the development of new techniques in human retrovirology, made it possible to investigate the role of this class of viruses in the etiology of schizophrenia. Cultures of peripheral lymphocytes of patients with chronic schizophrenia were established and tested for the retrovirus- specific enzyme reverse transcriptase.

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