CHEMICAL ANTIDEPRESSANT EFFECTS ON BODY MASS AND BODY COMPOSITIION IN HAMSTERS

在人类身上，慢性化学物质的副作用之一 抗抑郁治疗是身体质量的改变。这个 这些诱发变化的机制尚不清楚，但可能包括 代谢率的变化以及对特定身体的影响 身体脂肪、蛋白质或水分等成分。我们有 先前注意到的化学抗抑郁剂诱导的改变 长期用药的叙利亚仓鼠的体质量 单胺氧化酶抑制剂(MAOI)Clorgyline。这个项目 是为了更正式地探索行为和 导致这些变化的生理机制 叙利亚仓鼠。 我们已经观察到，最初的clorgyline治疗减少了食物 入口处。在慢性用药期间，Clorgyline 管理降低体重增加的速度，尽管水平 食物摄入量与对照组没有什么不同。因此，药物治疗 仓鼠每单位体重消耗的食物比 控制动物，即它们表现出负能量平衡 相对于控制动物。 Clorgyline处理后的屠体成分分析 仓鼠表明药物诱导的变化是由于 减少体内脂肪含量，而不是蛋白质或水分。 由于身体质量的季节性变化是由于 体脂含量，我们的结果表明Clorgyline可能是 影响相同的光周期过程，这是负责 光周期引起的叙利亚人体重的变化 仓鼠。

In humans, one of the side effects of chronic chemical antidepressant treatment is a change in body mass. The mechanism of these induced changes is not clear but may include alterations in metabolic rate, as well as effects on specific body components such as body lipid, protein or water. We have previously noted chemical antidepressant induced alterations in the body mass of Syrian hamsters being treated chronically with the monoamine oxidase inhibitor (MAOI) clorgyline. This project was undertaken to more formally explore the behavioral and physiological mechanisms responsible for these alterations in Syrian hamsters. We have observed that initial clorgyline treatment decreases food intake. During chronic drug administration, clorgyline administration reduces the rate of weight gain although the level of food intake is not different from control. Thus, drug treated hamsters consume more food per unit of body mass than do control animals, i.e., they exhibit a negative energy balance relative to control animals. Analysis of the carcass composition of clorgyline treated hamsters indicates that drug induced changes are due to a decrease in body lipid content, rather than protein or water. SINCE seasonal changes in body mass are due to fluctuations in body lipid content, our results indicate that clorgyline may be affecting the same photoperiodic process which is responsible for photoperiodic-induced changes in body mass in the Syrian hamster.