课题基金 / 基金详情

WOODCHUCK HEPATITIS VIRUS

WOODCHUCK HEPATITIS VIRUS
土拨鼠肝炎病毒
批准号：
3960540
负责人：
R H PURCELL
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3960540
关键词：
active immunization animal viral hepatitis antigen antibody reaction antiviral antibody cancer prevention chronic disease /disorder disease /disorder model duck hepatitis B virus hepatitis B antigens hepatitis vaccine hepatocellular carcinoma neoplasm /cancer immunotherapy newborn animals oncogenic virus serology /serodiagnosis virus infection mechanism virus related neoplasm /cancer

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相关文献

中文摘要
翻译
土拨鼠肝炎病毒（WHV）是分类和血清学 与B型肝炎病毒（HBV）有关。 感染这些病毒 病毒与急性和慢性肝炎及肝细胞 癌在各自的宿主;这些协会似乎是 本质上是病因学的。 WHV/土拨鼠模型系统提供了一个 研究病毒与宿主关系的简便方法， 致癌过程 WHV抗原-抗体系统特异性检测 已经被开发出来了。 嗜肝DNA病毒与 逆转录病毒有共同的起源 基因改变的WHV基因组， 正在土拨鼠中研究通过重组DNA技术构建的 为了确定单个基因的生物学意义， 产品.
英文摘要
The woodchuck hepatitis virus (WHV) is taxonomically and serologically related to the hepatitis B virus (HBV). Infection with each of these viruses is associated with acute and chronic hepatitis and hepatic cell carcinoma in their respective hosts; these associations appear to be etiological in nature. The WHV/woodchuck model system provides a convenient means of studying the relationship between virus and host in the oncogenic process. Tests specific for the WHV antigen-antibody systems have been developed. Genetic relationships between the hepadnaviruses and retroviruses suggest a common origin. Genetically altered WHV genomes, constructed by recombinant DNA techniques are being studied in woodchucks in order to determine the biological significance of individual gene products.
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