A STUDY OF SPORADIC NEUROASTHENIA ASSOCIATED WITH EPSTEIN-BARR VIRUS

这个项目的目标是描述一种慢性疲劳综合症和 以确定爱泼斯坦-巴尔病毒是否在其病因中起作用。我们 已经确定并正在进一步探索一系列临床和 部分患者出现免疫异常。我们几乎完成了一项 阿昔洛韦治疗27例慢性前列腺癌患者的大型安慰剂对照试验 不寻常的爱泼斯坦-巴尔病毒血清学特征。我们的愿望是确定 化疗是否会改变症状、病毒脱落率或任何 我们观察到的一系列免疫异常。我们计划的研究 在这一领域，涉及到对开始患病的个人的高度关注 有充分记录的急性传染性单核细胞增多症和分子 从它们身上恢复了病毒的性质。

The goal of this project is to characterize a chronic fatigue syndrome and to ascertain whether Epstein-Barr virus plays a role in its causation. We have identified and are further exploring a series of clinical and immunologic abnormalities in some patients. We have nearly completed a large placebo controlled trial of acyclovir therapy in 27 patients with unusual Epstein-Barr virus serologic profiles. Our desire is to determine whether chemotherapy alters symptoms, virus shedding rates or any of a series of immunologic abnormalities we have observed. Our planned studies in this area involve a heightened focus on individuals whose illness began with well documented acute infectious mononucleosis and on the molecular properties of virus recovered from them.