Nano-diffusion in the brain: mechanisms and implications examined with time-resolved fluorescence anisotropy imaging

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Rapid movements of signalling molecules underlie the functioning of neural circuitries at all levels of information handling in the brain, from individual cell-cell connections to cognitive activity, in health and disease. Our aim is to understand molecular mechanisms that control this relationship. To achieve this, we will adapt a recent technological breakthrough in physics allowing the monitoring of molecular mobility on the scale of nanoseconds. Results obtained with this novel methodology should ultimately unveil previously unknown targets for drug action.