2-Methoxyestradiol analogues: prototype modulators of annexin II-dependent plasminogen activation

使我们能够溶解血栓的酶系统类似于使癌细胞能够从原发肿瘤逃逸并在血液中移动到另一个器官以形成继发性癌症生长的系统。我们有新的结果表明，一些候选药物可以区分这两个密切相关的酶系统。我们现在正在努力开发一种抑制剂，可以在不影响溶解血栓的能力的情况下阻止癌细胞的扩散。

The enzyme system that enables us to dissolve blood clots is similar to the system that enables cancer cells to escape from the primary tumour and travel in the blood to another organ to form a secondary cancer growth. We have new results showing that some drug candidates can distinguish between these two closely related enzyme systems. We are now working to develop inhibitors that will stop cancer cells from spreading without compromising the ability to dissolve blood clots.