High throughput Sequencing Hub for the North of England

DNA序列一直是医学和临床研究进步的重要灵感来源。这最终导致了第一个人类基因组的测序，这个项目花了6-8年的时间和数十亿英镑。结果，我们能够发现定义人类形态的基因的数量和身份，尽管要弄清楚这些基因是如何相互作用的需要更长的时间。但我们知道，人们在疾病易感性或对治疗的反应方式上存在差异。目前的需要是了解这种变异的基础，并利用它来更充分地了解如何为出现特定情况的特定患者定义最合适的治疗方法。这就是所谓的？个性化药物？这被广泛认为是优化治疗的最佳方式。要实现这一点，需要在这些患者中建立特定基因的DNA序列，这需要更有成效的测序技术。幸运的是，现在有了新的仪器，它可以在短短几周内对一个人进行测序，大约需要10-5万英镑。先进基因组学设施(AGF)位于利物浦，是英国领先的卓越中心，也是新一代测序技术的服务提供商。我们希望扩大AGF的能力，为英格兰北部大学和医院的研究领导者提供一站式服务，为工作的所有阶段提供建议。我们还将提供培训和主要成本分担计划，帮助客户群体将DNA序列转化为知识。

DNA sequence has always been an important source of inspiration for advances in medical and clinical research. This culminated in the sequencing of the first human genome, a project that took 6-8 years and several billion pounds. As a result we were able to discover the number and identity of genes that defined the human form though it is taking much longer to work out how these genes interact. But we know that people vary from each other in their disease susceptibility or in the way that they respond to treatment. The current need is to understand the basis of this variation and to use it to understand more fully how to define the most appropriate treatment to particular patients presenting with a particular condition. This is called ?personalised medicine? and it is widely thought to be the best way of optimising treatment.Achieving this requires establishing the DNA sequence of particular genes in those patients, and this requires much more productive sequencing technologies. Fortunately, new instruments are now becoming available which can sequence a human in just a few weeks for approx #10-50,000. The Advanced Genomics Facility (AGF), located in Liverpool, is a leading UK centre of excellence and service provider for the new generation of sequencing technologies. We want to expand the capacity of the AGF to serve the research leaders in Universities and hospitals of the North of England by offering a one-stop shop that provides advice for all stages of the work. We shall also provide training and pump-prime cost-sharing programmes helping client groups to turn DNA sequence into knowledge.