Effect of Inorganic Nitrite on Cardiac and Skeletal Muscle: Physiology, Pharmacology and Therapeutic Potential

食用绿色蔬菜和甜菜根会增加血液中一种叫做亚硝酸盐的化学物质的浓度。最近的证据表明，当这种化学物质的浓度通过饮食增加意味着肌肉更有效地工作，需要更少的氧气。我们将调查发生这种情况的原因。心肌是另一种类型的肌肉，我们将研究亚硝酸盐对心肌是否有类似的作用。最后，我们将研究这种方法是否可以用于治疗腿部和心脏动脉阻塞等疾病。

Consumption of green vegetables and beetroot increases the concentration in the bloodstream of a chemical called nitrite. Recent evidence suggests that when the cncentration of this chemical is increased by dietary means muscle works more efficiently and requires less oxygen. We will investigate why this occurs. Heart muscle is another type of muscle and we will investigate whether nitrite has a similar effect in heart muscle. Finally we will investigate whether this can be exploited as a treatment in conditions such as blockage of the arteries of the leg and the heart.