LIVER METABOLISM PROGRAM PROJECT

肝脏代谢计划项目(LMPP)由一组密切相关的 与肝细胞代谢功能有关的相关研究项目。 脂肪、碳水化合物、蛋白质和胶原代谢的研究以及 肝脏药物代谢系统和肝细胞转运过程 积极调查。许多项目是合作的，有些项目是密切合作的 与独立资助的新研究项目进行互动 LMPP的成功。大多数项目都利用了细胞培养核心设施 它已经开发出改进的肝细胞单层培养技术。这 相对较新的方法已经被用来促进对 代谢和运输过程，并核实或确认观察到的 其他技术，体外或体内。续期期间的重点 将涉及以下代谢功能：合成磷脂和 中性脂类对毒素的反应和生理变化，胆汁的控制 肝脏胶原的酸合成、代谢、生物合成和周转 肝细胞色素，调节肝糖异生，形成 补体蛋白与胆汁酸等物质对转运的影响 肝细胞的功能。该项目有：先进的肝脏知识 新陈代谢；吸引了其他领域的研究人员进入肝脏研究； 为更好地开发肝脏单层培养技术做出了贡献 新陈代谢研究。

The Liver Metabolism Program Project (LMPP) consists of a group of closely related research projects concerned with metabolic functions of the hepatocyte. Studies of lipid, carbohydrate, protein, and collagen metabolism as well as the liver drug metabolizing system and liver cell transport processes are under active investigation. Many of the projects are collaborative and some closely interact with independently funded new research programs encouraged by the success of the LMPP. Most projects have utilized the cell culture core facility which has developed improved techniques for hepatocyte monolayer culture. This relatively new methodology has been exploited to advance understanding of metabolic and transport processes and to verify or confirm observations from other techniques, in vitro or in vivo. The emphasis during the renewal period will concern the following metabolic functions: synthesis of phospholipids and neutral lipids in response to toxins and physiological changes, control of bile acid synthesis, metabolism of liver collagen, the biosynthesis and turnover of hepatic cytochromes, the regulation of hepatic gluconeogenesis, the formation of complement proteins and the effects of agents including bile acids on transport functions of the hepatocyte. The project has: advanced knowledge of liver metabolism; attracted investigators from other fields into studies of the liver; and contributed to better exploitation of hepatic monolayer culture for metabolic studies.