Detection of Cardiac Allograft Rejection by Peripheral Blood Gene Expression: A Novel Concept of Personalized Approach to Transplantation.

为了检测心脏移植后的排斥反应，需要进行心脏活检。每次活组织检查的费用约为7000美元，仅在移植后的第一年就需要至少10次心脏活组织检查。活检对患者来说是困难的，对澳大利亚的医疗保健系统来说成本很高。因此，通过简单的血液测试来识别排斥反应是有益的。这种工具将有助于减少或消除对昂贵的心脏活检的需要，并将成本降低约10倍。

Heart biopsy is required to detect rejection after heart transplantation. The cost of each biopsy is around $7,000 and at least 10 heart biopsies needed in the first post-transplant year alone. The biopsy is difficult for the patients and significant cost for the Australian healthcare system. Thus, it would be beneficial to identify rejection using a simple blood test. Such tool would help to reduce or eliminate the need for expensive heart biopsy and would reduce the cost by about 10 times.