CYTOPATHOLOGY OF ASBESTOS AND OTHER FIBERS ON HUMAN LUNG CELLS IN CULTURE

我们实验室正在研究石棉纤维对人体的细胞病理学 人支气管上皮细胞、人间皮细胞和人成纤维细胞 在文化上。电子显微镜研究表明吞噬细胞 中期铺展的纤维和相显微镜显示频繁 纤维附着在染色体上。有关的调查 石棉致癌机制提示氧自由基是 可能不是重要的中间人。进一步的研究已经检验了 玻璃纤维和碳-石墨等合成纤维对人体的细胞毒性 间皮细胞培养。

Our laboratory is studying the cytopathology of asbestos fibers on human bronchial epithelial cells, human mesothelial cells and human fibroblasts in culture. Electron microscopy studies have demonstrated phagocytosis of the fibers and phase-microscopy of metaphase spreads reveal frequent attachment of the fibers to the chromosomes. Investigations regarding the mechanism of asbestos carcinogenesis suggest that oxygen radicals are probably not important intermediates. Further studies have examined the cytotoxicity of synthetic fibers, i.e., glass and carbon-graphite, on human mesothelial cell cultures.