正常和功能改变状态下的唾液腺分泌机制-猫眼课题宝

正常和功能改变状态下的唾液腺分泌机制

批准号：

4692638

负责人：

B J BAUM

金额：

$0.0万

依托单位：

NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/4692638

关键词：

X ray aging basolateral membrane biological models calcium metabolism drug adverse effect electrolytes exocrine glands ion transport neural information processing neurotransmitters oral health parasympathetic nervous system phenothiazines radiobiology salivary glands secretion submandibular gland vesicle /vacuole

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中文摘要

翻译

口腔的健康是由唾液分泌物维持的。的唾液腺的主要功能是产生这些复杂的液体。我们利用体外和体内制备的大鼠唾液腺主要是为了了解控制唾液形成的机制。我们有我们的研究主要集中在自主神经递质对分泌的调节，正常、衰老和两类治疗诱导的唾液腺事件功能障碍（X射线，吩噻嗪）。在本报告特定时期的研究领域是（1）进一步研究机械腮腺基底外侧质膜对Ca ~（2+）的处理过程;（2）确定Na+，K+，2Cl转运的存在和重要性腮腺液分泌的机制;（3）腮腺液分泌的可能调节作用腮腺分泌物中VIP（血管活性肠多肽）;（4）氯丙嗪作为竞争性毒蕈碱拮抗剂的评价;和（5）大鼠上皮细胞系建立及其生物学特性下颌下腺

英文摘要

The health of the oral cavity is maintained by salivary secretions. The principal function of salivary glands is to produce these complex fluids. We utilize both in vitro and in vivo preparations of rat salivary glands primarily to understand mechanisms controlling saliva formation. We have focused our studies on autonomic neurotransmitter regulation of secretory events in normal, aging and two types of therapy-induced salivary gland dysfunctions (X-radiation, phenothiazines). During the present reporting period specific areas of study were (1) further examination of mechanistic processes in Ca2+ handling by parotid basolateral plasma membrane; (2) determination of the presence, and importance, of a Na+, K+, 2 Cl transport mechanism in parotid fluid secretion; (3) the possible regulatory role of VIP (vasoactive intestinal polypeptide) in parotid secretion; (4) the evauation of chlorpromazine as a competitive muscarinic antagonist; and (5) the development and characterization of an epithelial cell line from rat submandibular glands.

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