VIROLOGIC AND IMMUNOPATHOLOGIC ASPECTS OF EYE DISEASES

眼科疾病的病毒学和免疫病理学方面正在由 免疫调节系统在视力和眼科疾病中的识别 并通过对病毒参与病原学和病原学的评价 眼科疾病的发病机制。 疾病的调节机制正在被研究，主要集中在 淋巴因子(干扰素、白介素2)与细胞的相互作用 眼内表面蛋白(HLADR、Ia)和选定的细胞(视网膜 色素上皮(RPE)细胞、光感受器、内皮细胞)。这些 研究发现干扰素系统和第二类抗原发生了变化。 在视网膜退行性变、炎症性眼病和选定的 免疫介导性疾病(获得性免疫缺陷综合症 (艾滋病)，自身免疫力)。开发单克隆的研究正在进行中 识别视网膜细胞(RPE)的抗体。由于RPE单元是一个 视网膜中重要的调节细胞，它们之间的相互作用 淋巴因子、II类抗原和RPE细胞功能正在评估中。 病毒在人类眼病病因和发病机制中的作用 目前正在对动物进行研究。从组织中识别病毒的尝试 葡萄膜炎和急性视网膜坏死的患者正在进行中。

Virologic and immunopathologic aspects of eye diseases are being studied by the identification of immunoregulatory systems in vision and ocular disease and by the evaluation of the involvement of viruses in the etiology and pathogenesis of eye diseases. Regulatory mechanisms in disease are being investigated by concentrating on the interactions among lymphokines (interferon (IFN), interleukin 2), cell surface proteins (HLA-DR, Ia) and selected cells within the eye (retinal pigment epithelial (RPE) cell, photoreceptors, endothelial cells). These studies have identified alterations in the IFN system and class II antigens in retinal degenerations, inflammatory eye diseases and in selected immunologically mediated diseases (Acquired Immunodeficiency Syndrome (AIDS), autoimmunity). Studies are in progress to develop monoclonal antibodies to identify retinal cells (RPE). Since the RPE cell is an important regulatory cell in the retina, the interactions among lymphokines, class II antigens and RPE cell function are being evaluated. The role of viruses in the etiology and pathogenesis of eye diseases in man and animals is being studied. Attempts to identify viruses in tissues from patients with uveitis and acute retinal necrosis are in progress.