CLINICAL PHENOMENA IN SCHIZOPHRENIA--QUANTIFICATION IN A EFFORT TO SUBTYPE

为了描述潜在的精神分裂症患者亚群，我们 研究了可量化的精神病理学、行为学和生理学 精神分裂症患者的变量。在精神病理学方面，我们有 做了两个研究：(1)从两个条目的分数中构造了一个商 BPR如下：怀疑/(无组织言论+怀疑)x 100.偏执型精神分裂症患者的商数得分较高(70分) 精神分裂症患者(47例，P<0.002)。(2)至 探讨精神病理学是否与TD在脑内的表达有关 我们在精神分裂症患者中检查了BPRS综合征簇 精神分裂症。TD患者以高度抑郁为主， 消极症状得分较低，但焦虑得分较低。在行为上，我们是 专注于精神分裂症的攻击性问题，并发现 精神分裂症患者比其他人更具攻击性 研究病人(40%以上对他人实施身体攻击) 这种攻击性往往与脑脊液减少有关 液体(CSF)、去甲肾上腺素(NE)和MHPG。最后一个生理变量 我们研究过的是尿量。慢性前列腺炎患者的平均尿量 精神分裂症的发病率是正常对照组的两倍(2300对1300毫升/24小时)。

To delineate potential discreet subgroups of patients with schizophrenia we have studied quantifiable psychopathological, behavioral, and physiological variables in schizophrenic patients. In terms of psychopathology we have done two studies: (1) Constructed a quotient of two item scores from the BPRS as follows: suspiciousness/(disorganized speech + suspiciousness) x 100. Patients with paranoid schizophrenia had a higher quotient score (70) than other patients with schizophrenia (47, p less than .002). (2) To examine whether psychopathology may be related to the expression of TD in schizophrenia we examined BPRS syndrome clusters in patients with schizophrenia. Patients with TD had a preponderance of high depression and negative symptoms scores but lower anxiety scores. Behaviorally we are concentrating on the issue of aggression in schizophrenia and have found that patients with schizophrenia are more aggressive than are other research patients (greater than 40% committed physical assaults on others) and that assaultiveness tended to be associated with reduced cerebrospinal fluid (CSF), norepinephrine (NE), and MHPG. A final physiological variable we have studied is urine volume. The mean volume of urine of patients with schizophrenia is twice that of normal controls (2300 vs 1300 ml/24hr).