LEFT VENTRICULAR FILLING BY PULSED DOPPLER ECHOCARDIOGRAPHY IN HCM

很少有真正的非侵入性测试可用于测量左 心脏病患者的心室舒张功能。 在这 在一项研究中，我们利用脉冲多普勒评估二尖瓣血流速度 在67例患者中， 肥厚型心肌病组35例，正常对照组35例。 患者 肥厚型心肌病患者与正常人明显不同， 舒张期快速充盈延长，舒张期缩短，充盈增强 心房收缩期间，（早期峰值流速比降低） 与心房收缩期的收缩幅度相当）和等容舒张时间延长。 67例患者中48例（72%）存在左室充盈异常 肥厚型心肌病，但在有症状的 (25/27，93%）比无症状患者（23/40; 57%; p <0.01）和 梗阻性（17/19，90%）比非梗阻性更常见 肥厚性心肌病（31/48，65%）; p <0.05）。 这些结果表明，脉冲多普勒超声心动图可用于 定量评价左心室功能， 左心室充盈和舒张是常见的，并且具有临床重要性 肥大性心肌病患者人群中的异常。

There are few truly non-invasive tests available to measure left ventricular diastolic function in patients with cardiac disease. In this study we utilized pulsed Doppler to assess transmitral flow-velocity patterns and characterize left ventricular filling and relaxation in 67 patients with hypertrophic cardiomyopathy and 35 normal controls. Patients with hypertrophic cardiomyopathy differed distinctly from normals with prolonged rapid diastolic filling, shortened diastasis, enhanced filling during atrial systole, (reduced ratio of peak flow-velocity in early diastole to that in atrial systole) and prolonged isovolumic relaxation. Abnormal left ventricular filling was present in 48 (72%) of 67 patients with hypertrophic cardiomyopathy, but was more common in symptomatic (25/27, 93%) than asymptomatic patients (23/40; 57%; p less than 0.01) and more frequent in obstructive (17/19, 90%) than in nonobstructive hypertrophic cariomyopathy (31/48, 65%); p less than 0.05). These findings demonstrate that pulsed Doppler echocardiography may be used to quantitatively assess left ventricular function and that impairment in left ventricular filling and relaxation are common and clinically important abnormalities in a population of patients with hypertrophic cariomyopathy.