Therapies for Long COVID in non-hospitalised individuals: From symptoms, patient-reported outcomes and immunology to targeted therapies (The TLC Study)

背景：一些在COVID-19感染中幸存下来的人会出现持续时间更长的症状，称为长COVID。许多人缺乏支持，并得到相互矛盾的建议。目的：找出哪些治疗方法最有可能使有特定症状的人受益，并测试支持性治疗以改善他们的生活质量。设计和方法工作包1将从全科医生记录中确定患有COVID-19的人。研究参与者将被邀请使用数字平台报告长期COVID症状/生活质量。工作包2将评估长COVID症状。有严重症状的参与者将由护士联系并提供建议/支持。血液检查结果和可穿戴数据将帮助我们了解哪种治疗方法最适合特定的长冠患者群体。工作包3将审查长期COVID治疗的证据，包括药物或支持性干预措施（例如心理健康或疲劳）。我们将与患者、医生和其他专家合作，推荐应在长COVID患者中进行测试的治疗方法，并开发可使用长COVID平台提供的支持性干预措施。工作包4将使用长COVID平台建立一个数字试验，以测试支持性干预措施是否可以通过减轻长COVID患者的症状和改善他们的生活质量而使他们受益，以及干预措施是否物有所值。有过COVID生活经历的人共同设计了这项研究计划和研究平台。一个生活经验顾问小组将在整个项目中与我们一起工作，并定期会面，为研究的各个方面做出贡献。传播结果将被出版，在会议上展示，并提供给其他研究人员使用。我们将建立一个专门的研究网站和Twitter账户，并将与我们的患者合作伙伴分享共同制作的摘要。

Background: Some people who have survived COVID-19 infection develop longer-lasting symptoms, known as Long COVID. Many lack support and are given conflicting advice. Aim: To work out which treatments are most likely to benefit people with particular symptoms and test supportive treatments to improve their quality of life. Design and methods Work package 1 will identify people that had COVID-19 from GP records. Study participants will be invited to use a digital platform to report Long COVID symptoms/quality of life. Work package 2 will assess Long COVID symptoms. Participants with severe symptoms will be contacted by a nurse to provide advice/support. Blood test results and wearable data will help us understand which treatments might be best to support specific groups of Long COVID patients. Work package 3 will review evidence for treatments for Long COVID including drugs or supportive interventions (e.g. for mental health or tiredness). Working with patients, doctors and other experts we will recommend treatments that should be tested in Long COVID patients and develop supportive interventions which can be delivered using the Long COVID platform. Work package 4 will establish a digital trial using the Long COVID platform to test whether supportive interventions can benefit Long COVID patients by reducing their symptoms and improving their quality of life and if the intervention is good value for money. Patient and public involvement People with COVID lived experience have co-designed this research proposal and the research platform. A lived experience advisory panel will work with us throughout the project and meet regularly to contribute to all aspects of the study. Dissemination Results will be published, presented at conferences and made available for use by other researchers. We will host a study specific website and Twitter account and will share lay summaries coproduced with our patient partners.