UNIVERSITY OF MICHIGAN MULTIPURPOSE ARTHRITIS CENTER

这项建议为大学的进一步发展制定了计划。 密歇根多功能关节炎中心(UMAC)。骨关节炎(OA) 在试点研究领域和主要研究领域受到特别重视 流行病学研究。UMAAC的总体目标继续包括： 1)发病机制和治疗的基础和临床研究 在几种风湿病中；2)继续教育/培训 医生和其他健康专业人员的计划，以满足学术 3)发展新教育 针对特定目标群体的计划；4)扩大一个独特的计划 以社区为基础的初级保健医生教育；以及5)评估 每一项教育工作都以最好的方法进行。已建立 研究计划将得到9个新的试验性研究项目的补充， 处理：一种新的骨关节炎动物模型，骨关节炎的生化机制，新的 与骨性关节炎相关的成像技术，三种不同的免疫细胞研究 幼年性关节炎的受体功能、人类白细胞抗原-DR表型和 病毒诱导的多发性肌炎小鼠模型。六个新的教育项目 对象：体育领域的教师、大学生 患有类风湿疾病的成人类风湿性关节炎，初级保健 公立学校的见习医生、青少年关节炎患者 类风湿神经畸形患者的设置和评估 用非手术方法治疗的。在社区项目中，一个新的组成部分 决定初级保健医生的关键因素研究 参与继续医学教育(CME)领域 风湿病被提出。它将利用之前收集的CME数据 并确定新信息如何到达初级保健 从业者。密歇根州特库姆塞的人口将被重新检查以 测量骨关节炎的发生率、退行性和进展性 骨质疏松症与20年前(1962-65)的研究结果相比较。一个 整个密歇根州的随机概率样本也将是 研究以提供对这两种情况的总体估计 并确定可能的干预策略。这些 研究、教育和社区项目将由 并入既定组织的行政单位 这所大学。提出了一种特殊的组织培养核心单元，用于 继续，因为它支持几个既定的研究方案 在这个中心内。UMAC有私人和国家的外部支持 机构，以及所需的机构支持，专业人士， 体力、体力和病人资源，以实现其规定的目标。

This proposal sets forth a plan for furthur development of the University of Michigan Multipurpose Arthritis Center (UMAC). Osteoarthritis (OA) is to receive special emphasis in the pilot research area and in a major epidemiologic study. The overall objectives of UMAC continue to include: 1) basic and clinical research dealing with the pathogenesis and treatment of the several rheumatic diseases; 2) continuation of education/training programs for physicians and other health professionals to meet the academic and patient car needs in the field; 3) development of new education programs for specific target groups; 4) expansion of a unique program of community-based education for primary care physicians; and 5) evaluation of each education effort by the best available methodology. Established research programs wll be complemented by 9 new pilot research projects that deal with: a new animal model of OA, biochemical mechanisms in OA, new imaging techniques relevant to OA, three different studies of immune cell receptor function, HLA-DR phenotypes in juvenile arthritis, and a virus-induced murine model of polymyositis. Six new educational projects target: teachers in the field of physical education, University students with rheumatoid disease, adults with rheumatoid arthritis, primary care physician trainees, juvenile arthritis patients in the public school setting, and assessment of rheumatoid patients with boutonniere deformities treated by nonsurgical means. In the community programs component a new study of critical factors which determine primary care physician involvement in continuing medical education (CME) in the field of rheumatology is proposed. It will utilize previously collected CME data and also determine how new information reaches the primary care practitioner. The population of Tecumseh, Michigan will be re-examined to measure the incidence, regression, and progression of osteoarthritis and osteoporosis as compared to findings 20 years previously (1962-65). A random probability sample of the entire state of Michigan will also be studied to provide estimates of these two conditions in the general population and to identify possible intervention strategies. These research, education, and community projects will be supported by an Administrative Unit that is integrated into the established organization of the University. A special Tissue Culture Core Unit is proposed for continuation since it supports several of the established research programs within this Center. UMAC has the external support of private and state agencies, as well as the required institutional support, professional, physical, and patient resources to achieve its stated objectives.