Medical and Regulatory Genomics

你的基因组中嵌入的基因具有复杂的活动模式，特定的基因星座必须在特定的细胞和特定的时间活跃，才能成功完成生物过程，如胚胎发育。我们小组对基因调控的基本生物学感兴趣：基因何时、如何以及为什么被开启和关闭。我们通过对测量数千个基因活性的数据集的计算分析，促进了对基因调控潜在机制的理解。这可以为人类进化本身提供新的见解，也有助于我们解释调控中断的疾病过程，如癌症和发育障碍。人类基因组在不同个体之间存在数百万个DNA位点的差异，但我们通常不知道哪些变异对我们的生物学最重要。最终，我们希望基于我们对基因调控的了解，开发预测模型，帮助我们预测变异对健康和疾病的影响。

The genes embedded in your genome have complex patterns of activity and particular constellations of genes must be active in particular cells and at particular times for biological processes, such as embryonic development, to conclude successfully. Our group is interested in the fundamental biology of gene regulation: when, how and why genes are turned on and off. We advance understand of the mechanisms underlying gene regulation, using computational analyses of datasets measuring the activities of many thousands of genes. This can provide new insights into human evolution itself, and also helps us to interpret disease processes with disrupted regulation, such as cancers and developmental disorders. Human genomes vary at millions of DNA sites between individuals, but often we do not know which variants matter most to our biology. Ultimately we want to develop predictive models, based upon our knowledge of gene regulation, that help us to forecast the effects of variants in health and disease.