Immunology of Digestive Disease

我们正致力于破译免疫系统对微生物的感知机制，以及在克罗恩病等疾病中，这种机制是如何受到干扰的。克罗恩病是一种主要的炎症性肠病，是由于肠道微生物和肠壁免疫细胞之间正常友好关系的破坏而导致的。我们在原代人类细胞中使用大规模的最先进的分子方法来破译炎症性疾病中紊乱的分子途径，以突出这些途径中可能适合治疗操作的分子。

We are working on deciphering mechanisms of sensing of microbes by the immune system and how that is perturbed in diseases such as Crohn’s disease, a major inflammatory bowel disease resulting from breakdown in the normally friendly relationship between microbes present in the bowel and immune cells present in the gut wall. We use large-scale state of the art molecular approaches in primary human cells to decipher molecular pathways that are deranged in inflammatory disease in order to highlight molecules in these pathways that may be amenable to therapeutic manipulation.