Cellular mechanisms of haematopoietic lineage commitment

这个项目将分析单个造血细胞及其在癌症、衰老和压力条件下(失血、感染)中所经历的变化，以了解人体如何应对和应对这些挑战。这将通过使用先进的DNA测序技术来测量每个单个细胞中表达哪些基因，以及这种模式在压力荷尔蒙存在的情况下如何变化，在包含导致白血病的突变的干细胞中，以及在老化的干细胞中。其目的是识别不同类型的造血干细胞，并找出这些群体在衰老过程中的变化。我们还将分析应激信号如何改变造血干细胞群体的组成并影响其分化模式。这将使我们能够根据需要设计和开发合理的治疗方法来促进或抵消这些变化。

This project will analyse individual blood forming cells and the changes they undergo in cancer, during aging and under stress conditions (blood loss, infection) to understand how the body deals with and responds to these challenges.This will be done by using advanced DNA sequencing technology to measure which genes are expressed in each individual cell, and how this pattern changes in the presence of stress hormones, in stem cells that contain mutations that cause leukaemia, and in aged stem cells. The aim is toidentify different types of of blood forming stem cells, andto find outhow these populations change during aging. We will also analyse alsohow stress signals alterthe composition of the hematopoietic stem cell populations and influences their differentiation pattern. This will enable us to design and develop rational therapies to promote or counteract these changes, as required.