Cognitive and neurobiological mechanisms underlying memory control.

国际上已经认识到，需要一种新的精神健康研究方法，专注于跨越精神诊断而不是诊断类别的症状的机制基础。这一方案独特地准备实现这一方法的承诺。我们试图找出一种关键的跨诊断症状的起源：持之以恒的思想，以侵扰性记忆、图像、沉思、病态担忧或强迫性思想的形式出现。思维控制障碍是抑郁症、焦虑症、创伤后应激障碍和强迫症等主要心理健康障碍最令人痛苦的症状之一。具体地说，我们将研究通过抑制控制来停止提取侵入性思维的能力，我们试图在认知、系统和电路水平上深入了解这一基本过程。我们的最终目标是在高水平认知理论和创新神经科学的推动下，开发有效的治疗目标和实际干预措施，主要包括基于训练、药理学和脑刺激的干预措施。

There is international recognition of the need for a new approach to mental health research that focuses on the mechanistic foundations of symptoms that cut across psychiatric diagnoses rather than diagnostic categories. This programme is uniquely poised to deliver on the promise of this approach. We seek to identify the origins of a crucial trans-diagnostic symptom: perseverative thoughts, in the form of intrusive memories, images, ruminations, pathological worries or obsessive thoughts. Disordered control over thought is amongst the most distressing symptoms of major mental health disorders, such as depression, anxiety, post-traumatic stress disorder and obsessive-compulsive disorder Specifically, we will investigate the ability to stop retrieval of intrusive thoughts via inhibitory control and we seek to understand this fundamental process deeply at the cognitive, systems, and circuit levels. Our ultimate objective is to develop validated treatment targets and practical interventions motivated by high level cognitive theory and innovative neuroscience, which main include interventions based on training, pharmacology, and brain stimulation.