Harnessing antigen-specific T cell immunity in time and space

库希教授的团队进行的这项研究深入研究了免疫系统的复杂世界，以了解它是如何抵御疾病的。我们关注的是一种叫做T细胞的免疫细胞，它在保护我们的身体方面起着关键作用。这些T细胞通过识别被感染细胞表面的特定分子（即抗原）来识别有害的入侵者。尽管这一过程很重要，但许多细节仍不清楚。为了解开这些谜团，该团队使用了先进的技术，如机器学习和单细胞创新实验。我们的目标是绘制出T细胞在不同情况下用来检测抗原的分子的详细图谱。我们也在努力了解T细胞在感染期间或接种疫苗后对不同情况的反应。这包括研究T细胞在身体不同部位随时间变化的分子表达模式。我们也在探索不使用常规标记就能识别入侵者的T细胞。为了破解这些谜题，我的团队将基于计算机的方法与对免疫系统工作原理的深入了解结合起来。我们正在与世界各地的专家合作，将这些复杂的免疫防御规则拼凑在一起。最终，这项研究可能会在我们如何理解和治疗疾病方面取得突破。

The research undertaken by Prof. Koohy’s group delves into the intricate world of the immune system to understand how it fights off diseases. We focus on a type of immune cell called T cells, which play a key role in protecting our bodies. These T cells recognize harmful invaders by identifying specific molecules, known as antigens, on the surface of infected cells. Despite the importance of this process, many details remain unclear. To unravel these mysteries, the team uses advanced techniques like machine learning and innovative experiments with single cells.Our goal is to create a detailed map of the molecules that T cells use to detect antigens in different contexts. We're also working on understanding how T cells respond to different situations, during infections or following administration of vaccines. This involves studying the changing patterns of molecules expressed by T cells over time and in different parts of the body. We're also exploring T cells that can recognize invaders without using the usual markers. To crack these puzzles, my team combines computer-based methods with deep knowledge of how the immune system works. We're collaborating with experts from around the world to piece together these intricate rules of immune defence. Ultimately, this research could lead to breakthroughs in how we understand and treat diseases.