Chromosomal instability in cancer pathogenesis and treatment

癌细胞内的遗传物质非常不稳定。我们工作的总体目的是了解这种不稳定性是如何促进癌症生长的，并利用这一新知识更好地确定人类癌症的遗传风险，并开发癌症检测和治疗的新方法。特别是，我们将研究胰腺癌，这是一个主要的死亡原因，有一个迫切的未满足的医疗需求，以提高检测和治疗。

The genetic material within cancer cells is highly unstable. The overall purpose of our work is to understand how this instability contributes to cancer growth, and to use this new knowledge to better pinpoint genetic risks for human cancer, and to develop new approaches for cancer detection and therapy. In particular, we will study pancreatic cancer, a leading cause of death, for which there is an urgent unmet medical need to improve detection and therapy.