A PROSPECTIVE STUDY OF ANTI-HCV POSITIVE BLOOD DONORS

这项研究自1992年以来一直在进行，当时血液中的抗HCV筛查 首先介绍了捐助者。 迄今为止的调查结果已进入最后阶段 准备提交给NEJM。主要调查结果如下： （与对照组进行比较，对照组通过EIA检测抗HCV，但 在RIBA特异性测定上为阴性）：（I）HCV的特征 与对照组相比，感染的供体年龄较小，非洲裔美国人 种族、较低教育水平和更频繁的肝脏病史 性功能障碍或性传播疾病;（2） 与HCV感染独立相关的是输血史， 性滥交，静脉注射毒品（IVDU），可卡因吸食和耳 男性穿刺;（3）令人惊讶的是，41%的志愿献血者给了一个 有静脉吸毒史;（4）HCVRNA阳性率为86%，证实了大多数 抗-HCV阳性者是慢性携带者，但提高 大约15%的人从这种感染中恢复的可能性;（5）有 没有证据表明性传播HC时，具体的合作伙伴是 （6）在77例抗-HCV阳性受试者中：92%的组织学检查 慢性肝炎和/或肝硬化的证据。(7)RIBA不确定 与RIBA阴性结果无法区分

This study has been ongoing since 1992 when anti-HCV screening of blood donors was first introduced. The findings to date are in the final stage of preparation for submission to NEJM. The major findings are as follows: (comparisons are with controls who tested anti-HCV by EIA, but were negative on the RIBA specificity assay): (I) Characteristics of HCV infected donors as compared to controls were younger age, African-American race, lower education level and a more frequent history of liver dysfunction or sexually transmitted disease; (2) Risk factors that were independently associated with HCV infection were histories of transfusion, sexual promiscuity, intravenous drug use (IVDU), cocaine snorting and ear piercing in males; (3) Surprisingly, 41% of volunteer blood donors gave a history of IVDU; (4) HCV RNA was present in 86%, confirming that most anti-HCV positive individuals are chronic carriers, but raising the possibility that approximately 15% recover from this infection; (5) There was no evidence for sexual transmission of HC when specific partners were tested; (6) Among 77 anti-HCV positive subjects: 92% had histological evidence of chronic hepatitis and/or cirrhosis. (7) RIBA indeterminates were indistinguishable from RIBA negatives.